Clozapine EP Impurity D CAS 65514-71-8
| CAS No. | 65514-71-8 |
| Molecular Formula | C18H21ClN4O |
| Molecular Weight | 344.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Clozapine EP Impurity D is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 344.84 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Clozapine EP Impurity D (CAS 65514-71-8) is a certified pharmaceutical impurity reference standard with the molecular formula C18H21ClN4O and a molecular weight of 344.84 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Clozapine EP Impurity D under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H21ClN4O |
| Molecular Weight | 344.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Clozapine Standards
Recommended Standards
- Cetirizine Dihydrochloride EP Impurity B (CAS 942193-17-1)
- Bifonazole Impurity 22 (CAS CATO-C4X-156022)
- N-[2-Amino-4-(4-methylpiperazino)phenyl]-3-chlorobenzenecarboxamide (CAS 439107-46-7)
- Clotrimazole Impurity 19 (CAS 23593-76-2)
- Bedaquiline Impurity 17 (CAS CATO-C4X-116717)
- Bifendate Impurity A (CAS 118159-47-0)
- Darunavir Impurity 40 (CAS 143225-31-4)
- (4,5-Difluoro-2-methoxyphenyl)methanamine (CAS 886497-93-4)
- Azilsartan (CAS 1675221-56-3)
- N-(2-acetamidophenyl)-2-chloroacetamide (CAS 36819-74-6)
- 6-Fluoro-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid hydrochloride (CAS 1260637-74-8)
- 4-Iodo-2,7-naphthyridin-1-amine (CAS 959558-53-3)
- 1-(4-Chloro-2,5-dimethoxyphenyl)-3-(1-methyl-1H-indazol-3-yl)thiourea (CAS 1858241-71-0)
- Copper Peptide ·2 acetate salt (CAS 130120-57-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com