Levothyroxine Impurity 16 CAS 4192-14-7
| CAS No. | 4192-14-7 |
| Molecular Formula | C15H13I2NO4 |
| Molecular Weight | 525.08 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Levothyroxine Impurity 16.
CATO supplies Levothyroxine Impurity 16 (CAS 4192-14-7), a certified reference material (molecular formula C15H13I2NO4, MW 525.08 g/mol) for analytical method development and quality control.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution, Levothyroxine Impurity 16 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 525.08 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Levothyroxine Impurity 16 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H13I2NO4 |
| Molecular Weight | 525.08 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Levothyroxine Standards
- rac-Levothyroxine EP Impurity J (3,3'-DL-Diiodothyronine) (CAS 70-40-6)
- Levothyroxine EP Impurity J (CAS 4604-41-5)
- Levothyroxine EP Impurity E (CAS 1041-01-6)
- Levothyroxine Impurity 37 (CAS 94345-95-6)
- Levothyroxine Impurity 18 (CAS 1155-40-4)
- Levothyroxine Impurity 38 (CAS 1027-28-7)
- Levothyroxine Impurity 58 (CAS 176258-87-0)
- Levothyroxine Impurity 42 (CAS 4618-45-5)
Recommended Standards
- 3,5-Diiodo-DL-thyronine (CAS 534-51-0)
- 3,5-Diiodo-D-thyronine (CAS 5563-89-3)
- VTP 27999 (CAS 942142-51-0)
- 2-(Benzylsulfanyl)-5-(4-chlorophenyl)-4-{2'-fluoro-4'-propyl-[1,1'-biphenyl]-4-yl}pyrimidine (CAS 478248-93-0)
- Methyl allyl(benzyl)carbamate (CAS 61357-21-9)
- 2-(3-Bromo-5-chloropyridin-2-yl)acetonitrile (CAS 1227515-01-6)
- 3-(Hydroxymethyl)-1-methyl-2-pyrrolidinone (CAS 577780-05-3)
- 2-Amino-5-Anilino-[1,4]Benzoquinone-4-Phenylimine (CAS 86711-33-3)
- Benproperine Impurity 8 (CAS 124678-30-4)
- 2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (CAS 84461-65-4)
- 2,2-Difluoro-1-(4-methylpiperazin-1-yl)ethanone (CAS 121412-30-4)
- 1-(2-(4-(2-Bromoethoxy)naphthalen-1-yl)benzofuran-3-yl)ethanone (CAS 61639-36-9)
- 1-(5-Bromopyrimidin-2-yl)cyclopropanecarboxamide (CAS 1447607-75-1)
- Semaglutide impurity 86 (CAS CATO-C4X-222686)
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