Dacomitinib Monhydrate CAS 1042385-75-0
| CAS No. | 1042385-75-0 |
| Molecular Formula | C24H25ClFN5O2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dacomitinib Monhydrate is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Dacomitinib Monhydrate (CAS 1042385-75-0), a certified reference material (molecular formula C24H25ClFN5O2H2O, MW 487.96 g/mol) for analytical method development and quality control.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Dacomitinib Monhydrate is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 487.96 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Dacomitinib Monhydrate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H25ClFN5O2 H2O |
| Molecular Weight | 487.96 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Dacomitinib Standards
- Dacomitinib (CAS 1110813-31-4)
- Dacomitinib Impurity 4 (CAS 179552-75-1)
- Dacomitinib Impurity N4 (CAS 2190490-31-2)
- Dacomitinib Impurity 22 (CAS 2250242-14-7)
- Dacomitinib Impurity 1 (CAS CATO-C4X-20861)
- Dacomitinib Impurity 10 (CAS CATO-C4X-208610)
- Dacomitinib Impurity 11 (CAS CATO-C4X-208611)
- Dacomitinib Impurity 12 (CAS CATO-C4X-208612)
Recommended Standards
- methyl 3-amino-3-(2,4-difluorophenyl)propanoate hydrochloride (CAS 1333750-44-9)
- 2-Cinnamoyl-1H-indene-1,3(2H)-dione (CAS 15548-49-9)
- 5-Chloro-2-isopropoxy-3-methylpyridine (CAS 1394976-13-6)
- 3-ethyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonyl chloride (CAS 878432-93-0)
- Ethyl 2-(3-fluoro-4-(trifluoromethyl)phenyl)thiazole-4-carboxylate (CAS 937602-41-0)
- (2S)-4,4-Difluoro-2-methylpyrrolidine-2-carboxylic acid (CAS 1363384-65-9)
- 2-bromo-1-(bromomethyl)-3-(2,2,2-trifluoroethoxy)benzene (CAS 1824284-85-6)
- Ethyl 4-hydroxy-5-oxo-1-(2-thienylmethyl)-2,5-dihydro-1H-pyrrole-3-carboxylate (CAS 131436-78-7)
- Tert-butyl 4-(2-cyanoethyl)piperazine-1-carboxylate (CAS 77278-86-5)
- [α-Glu](Side Chain)-Semaglutide (CAS CATO-C4X-2226159)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com