Dacomitinib Impurity 4 CAS 179552-75-1
| CAS No. | 179552-75-1 |
| Molecular Formula | C15H12ClFN4O |
| Molecular Weight | 318.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Dacomitinib Impurity 4.
Dacomitinib Impurity 4 (CAS 179552-75-1) is a certified pharmaceutical impurity reference standard with the molecular formula C15H12ClFN4O and a molecular weight of 318.73 g/mol.
Dacomitinib Impurity 4 (C15H12ClFN4O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Dacomitinib Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H12ClFN4O |
| Molecular Weight | 318.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2008 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Dacomitinib Standards
- Dacomitinib Impurity 31 (CAS CATO-C4X-208631)
- Dacomitinib Impurity 40 (CAS CATO-C4X-208640)
- Dacomitinib Impurity 44 (CAS CATO-C4X-208644)
- Dacomitinib Impurity 43 (CAS CATO-C4X-208643)
- Dacomitinib Impurity 29 (CAS CATO-C4X-208629)
- Dacomitinib Impurity 26 (CAS CATO-C4X-208626)
- Dacomitinib Impurity 30 (CAS CATO-C4X-208630)
- Dacomitinib Impurity 39 (CAS CATO-C4X-208639)
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