Dacomitinib Impurity 1 CAS CATO-C4X-20861
| CAS No. | CATO-C4X-20861 |
| Molecular Formula | C24H25ClFN5O3 |
| Molecular Weight | 485.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Dacomitinib Impurity 1 (CAS CATO-C4X-20861), a pharmacopoeial impurity reference standard (molecular formula C24H25ClFN5O3, MW 485.94 g/mol) used for the identification and quantification of trace impurities in APIs.
Dacomitinib Impurity 1 (C24H25ClFN5O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H25ClFN5O3 |
| Molecular Weight | 485.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Dacomitinib Standards
- Dacomitinib Impurity 37 (CAS CATO-C4X-208637)
- Dacomitinib Impurity 48 (CAS CATO-C4X-208648)
- Dacomitinib Impurity 51 (CAS CATO-C4X-208651)
- Dacomitinib Impurity 45 (CAS CATO-C4X-208645)
- Dacomitinib Impurity 42 (CAS CATO-C4X-208642)
- Dacomitinib Impurity 54 (CAS CATO-C4X-208654)
- Dacomitinib Impurity 47 (CAS CATO-C4X-208647)
- Dacomitinib (CAS 1110813-31-4)
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Why CATO?
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