Atrasentan Impurity 50 CAS 1059056-96-0
| CAS No. | 1059056-96-0 |
| Molecular Formula | C37H54N2O6 |
| Molecular Weight | 622.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Atrasentan Impurity 50.
As a process- or degradation-related impurity, Atrasentan Impurity 50 (CAS 1059056-96-0, C37H54N2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Atrasentan Impurity 50 (C37H54N2O6) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C37H54N2O6 |
| Molecular Weight | 622.85 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 2 |
Related Atrasentan Standards
- Atrasentan Impurity 103 (CAS 1059052-06-0)
- Atrasentan Impurity 110 (CAS 1059052-60-6)
- Atrasentan Impurity 141 (CAS 1058349-21-5)
- Atrasentan Impurity 177 (CAS 1059052-00-4)
- Atrasentan Impurity 53 (CAS 1059057-02-1)
- Atrasentan Impurity 63 (CAS 1140456-19-4)
- Atrasentan Impurity 96 (CAS 1059043-54-7)
- Atrasentan Impurity 98 (CAS 1059043-59-2)
Recommended Standards
- Olanzapine Impurity 36 (CAS CATO-C4X-117836)
- Dronedarone Impurity 39 (CAS CATO-C4X-109239)
- Olanzapine Impurity 35 (CAS CATO-C4X-117835)
- Pseudoginsenoside Rh2 (CAS 1370264-16-6)
- Alvimopan impurity 18 (CAS CATO-C4X-114518)
- Allopurinol Impurity 31 (CAS CATO-C4X-145831)
- Sorafenib EP Impurity H (CAS 1431697-81-2)
- Ticagrelor Impurity 43 (CAS 145783-13-7)
- 3-(2,4,6-Trimethylphenyl)-1-propene (CAS 4810-05-3)
- 10-Methyl-3,4-dihydro-2H-pyrano[3,2-b]quinoline hydrochloride (CAS 94411-41-3)
- 3-(1-Methyl-1H-imidazol-2-yl)-2,4,5,5a,6,7,8,8a-octahydro-pyrrolo[3,4-g]indazole trihydrochloride (CAS 1361113-77-0)
- 3-(Methoxymethoxy)propanenitrile (CAS 52406-33-4)
- 1-(2-(2,4-Dichlorophenoxy)propionyl)-4-benzylthiosemicarbazide (CAS 288154-62-1)
- Peptide Impurity 28 (CAS 1350456-64-2)
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