Resmetirom Impurity 20 CAS 107228-52-4
| CAS No. | 107228-52-4 |
| Molecular Formula | C10H14Cl2N2 |
| Molecular Weight | 233.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Resmetirom Impurity 20 (C10H14Cl2N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Resmetirom Impurity 20 (CAS 107228-52-4) is a certified pharmaceutical impurity reference standard with the molecular formula C10H14Cl2N2 and a molecular weight of 233.14 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Resmetirom Impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H14Cl2N2 |
| Molecular Weight | 233.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Resmetirom Standards
- Resmetirom impurity 96 (CAS CATO-C4X-291296)
- Resmetirom impurity 53 (CAS 79694-26-1)
- Resmetirom impurity 54 (CAS 62918-73-4)
- Resmetirom impurity 55 (CAS 17742-65-3)
- Resmetirom impurity 70 (CAS CATO-C4X-291270)
- Resmetirom impurity 74 (CAS 116688-45-0)
- Resmetirom Impurity 45 (CAS CATO-C4X-291245)
- Resmetirom Impurity 4 (CAS 107228-51-3)
Recommended Standards
- Tucatinib Impurity 41 (CAS CATO-C4X-260541)
- 4-bromoisoquinolin-3-amine (CAS 10321-49-0)
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- 2-bromo-2-methyl-1-phenylpropan-1-one (CAS 10409-54-8)
- Dalilesen impurity 40 (CAS CATO-C4X-301040)
- Trimipramine EP Impurity C HCI (CAS 1159-80-4)
- Solifenacin EP impurity F HCl (CAS 180468-40-0)
- 2-(4-Bromophenyl)-5-(tert-butyl)oxazole (CAS 1351385-48-2)
- 3-Chloro-6-[(2-fluorophenyl)methyl]pyridazine (CAS 200001-63-4)
- 6'-Bromospiro[cyclopropane-1,3'-pyrrolo[3,2-b]pyridin]-2'(1'H)-one (CAS 1823524-95-3)
- 1,1-Dimethylguanidine hydrochloride (CAS 22583-29-5)
- 2,2,2-Chlorodifluoroacetophenone 2-CHLORO-2,2-DIFLUOROACETOPHENONE 384-67-8 ALPHA,ALPHA-DIFLUOROPHENACYL CHLORIDE ALPHA-CHLORO-ALPHA,ALPHA-DIFLUOROACETOPHENE ALPHA-CHLORO-ALPHA,ALPHA-DIFLUOROACETOPHENONE AS01171 CHLORODIFLUOROACETOPHENONE (CAS 384-67-8)
- (1s)-1-Phenylpentan-1-ol (CAS 33652-83-4)
- Peptide 439 (CAS CATO-CPTD788439)
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