Resmetirom Impurity 4 CAS 107228-51-3
| CAS No. | 107228-51-3 |
| Molecular Formula | C7H8Cl2N2 |
| Molecular Weight | 191.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 191.06 g/mol gives Resmetirom Impurity 4 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Resmetirom Impurity 4 (CAS 107228-51-3, C7H8Cl2N2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C7H8Cl2N2, Resmetirom Impurity 4 contains a nitrile group, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 191.06 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Resmetirom Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H8Cl2N2 |
| Molecular Weight | 191.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Resmetirom Standards
- Resmetirom Impurity 45 (CAS CATO-C4X-291245)
- Resmetirom impurity 134 (CAS 28165-63-1)
- Resmetirom impurity 64 (CAS 2375196-15-7)
- Resmetirom impurity 65 (CAS 1696366-11-6)
- Resmetirom impurity 70 (CAS CATO-C4X-291270)
- Resmetirom impurity 53 (CAS 79694-26-1)
- Resmetirom impurity 54 (CAS 62918-73-4)
- Resmetirom impurity 133 (CAS 1314924-95-2)
Recommended Standards
- Opicapone impurity 66 (CAS 1639373-19-5)
- 2-Bromo-2-methylcyclohexanone (CAS 10409-47-9)
- Anagrelide Impurity 10 (CAS 147249-42-1)
- 2-Bromocycloheptan-1-one (CAS 1056246-49-1)
- Baloxavir Impurity 5 (CAS CATO-C4X-21085)
- Losartan EP Impurity D (CAS 83857-96-9)
- Iohexol EP Impurity E (CAS 2727061-52-9)
- Potassium (E)-4-(4-methoxystyryl)pyrimidine-2-thiolate (CAS 318248-58-7)
- Dilauryl hydrogen phosphite (CAS 21302-90-9)
- Diphenyliodonium Hexafluorophosphate (CAS 58109-40-3)
- 1220029-64-0 2042AD 4-{2-[2-Bromo-4-(tert-butyl)phenoxy]-ethyl}piperidine hydrochloride C17H27BrClNO (CAS 1220029-64-0)
- 2-Bromo-4,5-dimethoxypyridine (CAS 1211520-13-6)
- 2,3-Diphenyl-5-(2-thienyl)tetrazolium Chloride (CAS 38800-20-3)
- Semaglutide impurity 257 (CAS CATO-C4X-2226257)
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