Resmetirom impurity 53 CAS 79694-26-1
| CAS No. | 79694-26-1 |
| Molecular Formula | C8H7Cl2NO2 |
| Molecular Weight | 220.05 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Resmetirom impurity 53.
As a process- or degradation-related impurity, Resmetirom impurity 53 (CAS 79694-26-1, C8H7Cl2NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Resmetirom impurity 53 (C8H7Cl2NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Resmetirom impurity 53 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7Cl2NO2 |
| Molecular Weight | 220.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Resmetirom Standards
- Resmetirom impurity 54 (CAS 62918-73-4)
- Resmetirom impurity 70 (CAS CATO-C4X-291270)
- Resmetirom Impurity 20 (CAS 107228-52-4)
- Resmetirom Impurity 45 (CAS CATO-C4X-291245)
- Resmetirom impurity 96 (CAS CATO-C4X-291296)
- Resmetirom Impurity 4 (CAS 107228-51-3)
- Resmetirom impurity 55 (CAS 17742-65-3)
- Resmetirom impurity 134 (CAS 28165-63-1)
Recommended Standards
- Avatrombopag Impurity 81 (CAS 401566-69-6)
- Bosutinib Impurity 26 (CAS 67669-19-6)
- Swep (CAS 1918-18-9)
- Methyl 5-amino-2,4-dichlorobenzoate (CAS 84228-48-8)
- Trilostane Impurity 10 (CAS CATO-C4X-213710)
- Enalapril Impurity 35 (CAS CATO-C4X-133435)
- Papaverine Impurity 14 Hcl (CAS 18694-10-5（free base）)
- 3-Fluoro-2-((tetrahydrofuran-3-yl)oxy)aniline (CAS 917909-42-3)
- 2-(4-(Aminomethyl)piperidin-1-yl)benzonitrile (CAS 871721-59-4)
- N-benzyl-N-ethyl-4-nitrobenzamide (CAS 349396-05-0)
- 6-Chloro-4-phenoxypyridin-3-amine (CAS 1330574-81-6)
- (E)-N-((2,4-dichlorobenzyl)oxy)-N'-(4-(thiophen-2-yl)pyrimidin-2-yl)formimidamide (CAS 865660-30-6)
- Ethyl 1-(4-chlorobenzyl)-3-(1H-pyrrol-1-yl)-1H-indole-2-carboxylate (CAS 339098-96-3)
- Semaglutide impurity 267 (CAS CATO-C4X-2226267)
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