Phloroglucinol Impurity 25 CAS 108-36-1
| CAS No. | 108-36-1 |
| Molecular Formula | C6H4Br2 |
| Molecular Weight | 235.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Phloroglucinol Impurity 25 is closely related to bromine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Phloroglucinol Impurity 25 (CAS 108-36-1), a pharmacopoeial impurity reference standard (molecular formula C6H4Br2, MW 235.90 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Phloroglucinol Impurity 25 (C6H4Br2) is characterized by bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4Br2 |
| Molecular Weight | 235.90 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Br-containing |
Related Phloroglucinol Standards
- Phloroglucinol Dihydrate EP Impurity D (CAS 491-45-2)
- Phloroglucinol Impurity 71 (CAS 112221-63-3)
- Phloroglucinol Impurity 72 (CAS 121034-97-7)
- Phloroglucinol Impurity 73 (CAS 112221-65-5)
- Phloroglucinol Aldehyde Triethyl Ether ; 100 MG (CAS 59652-88-9)
- Phloroglucinol Impurity 58 (CAS 221652-95-5)
- Phloroglucinol impurity 44 (CAS 23957-21-3)
- Phloroglucinol Impurity 63 (CAS CATO-C4X-221763)
Recommended Standards
- 2,2-Dibromo-2-fluoroacetic acid (CAS 353-99-1)
- 1,2-Dibromobenzene (CAS 583-53-9)
- (2,4-Dichloro-5-nitrophenyl)boronic acid (CAS 1072952-12-5)
- 1,4-Dibromobenzene (CAS 106-37-6)
- CAS 2797598-85-5 (CAS 2797598-85-5)
- Regadenoson Impurity 42 (CAS CATO-C4X-198542)
- Varenicline Impurity 72 (CAS CATO-C4X-196272)
- 2-Bromo-N-[3-(phenethyloxy)phenyl]acetamide (CAS 71218-43-4)
- 2-Oxaspiro[3.3]heptan-5-ol (CAS 1823371-47-6)
- Iso Cyclosporin H TFA Salt (CAS 83602-43-1 (free amine))
- methyl 4-chloro-1H-indole-6-carboxylate (CAS 885522-78-1)
- 2-(Cyclopropylamino)-2-(pyridin-3-yl)acetic acid (CAS 1218388-85-2)
- Tofacitinib Impurity 113 (CAS CATO-C4X-1079113)
- Tirzepatide Impurity 51 (CAS CATO-C4X-324051)
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