Etizolam Impurity 4 CAS 110753-14-5
| CAS No. | 110753-14-5 |
| Molecular Formula | C13H10ClNO2S |
| Molecular Weight | 279.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Etizolam Impurity 4.
Etizolam Impurity 4 (CAS 110753-14-5) is a certified pharmaceutical impurity reference standard with the molecular formula C13H10ClNO2S and a molecular weight of 279.74 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Etizolam Impurity 4 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 279.74 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H10ClNO2S |
| Molecular Weight | 279.74 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Etizolam Standards
- Etizolam Impurity 14 (CAS 40054-57-7)
- Etizolam Impurity 12 (CAS 67727-22-4)
- Etizolam Impurity 5 (CAS CATO-C4X-35095)
- Etizolam Impurity 7 (CAS 91663-72-8)
- Etizolam Impurity 15 (CAS 51687-58-2)
- Etizolam Impurity 20 (CAS 50508-61-7)
- Etizolam Impurity 8 (CAS 54123-29-4)
- Etizolam Impurity 27 (CAS CATO-C4X-350927)
Recommended Standards
- N-(Chloro-phenyl-methylene)-benzenesulfonamide (CAS 4513-25-1)
- 4-Chloro-N-[2-(4-hydroxyphenyl)ethyl]benzamide-d4 (CAS 1189464-84-3)
- N-(4-Acetylphenyl)-5-chlorothiophene-2-carboxamide (CAS 391225-63-1)
- 2-(2-Chloropyrimidin-4-yl)-6,6-dimethyl-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one (CAS 1951483-81-0)
- Venlafaxine EP Impurity E HCl (CAS 93413-56-0)
- Pazufloxacin Impurity 3 (CAS CATO-C4X-23323)
- Hyoscine Butylbromide EP Impurity F Iodine (CAS CATO-C4X-195812)
- 1-(Tert-butyl)-3-iodobenzene (CAS 58164-02-6)
- (E)-3-(2-(methylamino)thiazol-5-yl)-3-oxopropanal O-(4-chlorobenzyl) oxime (CAS 338400-19-4)
- 2-(methoxymethyl)-4-(piperidin-3-yl)pyrimidine (CAS 914299-49-3)
- 1-Mesityl-2-phenyl-1H-imidazole (CAS 1093072-00-4)
- 8-L-Valineadrenorphin (human) (CAS 88866-92-6)
- (3,5-Diaminophenyl)(morpholino)methanone (CAS 313233-13-5)
- [D-Ser8]-Semaglutide A (CAS CATO-C4X-2226116)
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