Entrectinib Impurity 2 CAS 1108745-33-0
| CAS No. | 1108745-33-0 |
| Molecular Formula | C14H12FN3 |
| Molecular Weight | 241.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Entrectinib Impurity 2 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Entrectinib Impurity 2 (CAS 1108745-33-0, C14H12FN3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Entrectinib Impurity 2 (C14H12FN3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 241.26 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C14H12FN3 |
| Molecular Weight | 241.26 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Entrectinib Standards
Recommended Standards
- Zonisamide impurity 9 (CAS CATO-C4X-17859)
- (5-Nitrothiophen-2-yl)(piperazin-1-yl)methanone (CAS 104554-65-6)
- 952578-08-4 (2E)-1-(3-Aminophenyl)-3-(4-fluorophenyl)prop-2-en-1-one MFCD01158832 (CAS 952578-08-4)
- 1-(Benzo[d]thiazol-2-ylmethyl)-1h-1,2,4-triazole-3-carbonitrile (CAS 1110935-24-4)
- Bortezomib Impurity N34 TFA salt (CAS 2363753-29-9)
- Ibrutinib Impurity 92 (CAS CATO-C4X-106492)
- Fovinaciclib Impurity 6 (CAS CATO-C4X-33866)
- Methyl 2-fluoro-5-nitro-4-(trifluoromethyl)benzoate (CAS 2702792-82-1)
- 1-(Tert-butoxycarbonyl)-1-azaspiro[3.3]Heptane-2-carboxylic acid (CAS 2344679-32-7)
- N-(1-methyl-2-trifluoromethylsulfanyl-ethyl)-nicotinamide (CAS 1204234-41-2)
- 1-Acetyl-5-fluoro-3-methylpyrrolidin-2-one (CAS 246181-65-7)
- Metolazone (CAS 17560-51-9)
- Iron(II) dodecanoate (CAS 21248-71-5)
- Semaglutide impurity 194 (CAS CATO-C4X-2226194)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com