Afoxolaner Impurity 19 CAS CATO-C4X-313719
| CAS No. | CATO-C4X-313719 |
| Molecular Formula | C22H12BrF6NO3 |
| Molecular Weight | 532.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Afoxolaner Impurity 19 (CAS CATO-C4X-313719), a pharmacopoeial impurity reference standard (molecular formula C22H12BrF6NO3, MW 532.23 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C22H12BrF6NO3, Afoxolaner Impurity 19 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 532.23 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H12BrF6NO3 |
| Molecular Weight | 532.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Afoxolaner Standards
- Afoxolaner Impurity 14 (CAS 1125726-30-8)
- Afoxolaner impurity 8 (CAS CATO-C4X-31378)
- Afoxolaner Impurity 17 (CAS CATO-C4X-313717)
- Afoxolaner impurity 4 (CAS CATO-C4X-31374)
- Afoxolaner Impurity 24 (CAS 1352722-19-0)
- Afoxolaner Impurity 15 (CAS CATO-C4X-313715)
- Afoxolaner Impurity 20 (CAS 1125812-60-3)
- Afoxolaner impurity 5 (CAS CATO-C4X-31375)
Recommended Standards
- (S)-6,6-Dibromo-2,2-bis(methoxymethoxy)-1,1-binaphthyl (CAS 389867-61-2)
- (3E)-3-{2-[2,6-dichloro-4-(trifluoromethyl)phenyl]hydrazin-1-ylidene}-1-{[3-(trifluoromethyl)phenyl]methyl}-2,3-dihydro-1H-indol-2-one (CAS 303985-33-3)
- (S)-6,6'-Dibromo-2,2'-bis(methoxymethoxy)-1,1'-binaphthyl (CAS 211560-97-3)
- 3,4-Dibromo-2,2,5,5-tetraphenyl-2,5-dihydrofuran (CAS 36992-21-9)
- Ketorolac Impurity 39 (CAS CATO-C4X-166939)
- Landiolol Impurity 79 (CAS CATO-C4X-262179)
- Saxagliptin Impurity N52 (CAS 1194836-75-3)
- Copper(1+), bis[1,2-ethenediylbis[diphenylphosphine]-P,P']-, chloride (CAS 102532-71-8)
- 2-(4-Amino-3-(difluoromethyl)-6-hydroxypyridin-2-yl)acetic acid (CAS 1805336-66-6)
- 4-Bromo-3-fluorobenzonitrile (CAS 133059-44-6)
- 5-((2-Chlorobenzyl)thio)-1,3,4-thiadiazol-2(3h)-imine (CAS 299442-99-2)
- 1-(3-Bromophenyl)-2-phenylethan-1-one (CAS 40396-53-0)
- rel-(1R,3R)-3-((tert-Butyldimethylsilyl)oxy)cyclohexanamine (CAS 2271478-54-5)
- Insulin degludec (CAS 844439-96-9)
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