Afoxolaner impurity 8 CAS CATO-C4X-31378
| CAS No. | CATO-C4X-31378 |
| Molecular Formula | C24H15ClF6N2O4 |
| Molecular Weight | 544.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 544.83 g/mol gives Afoxolaner impurity 8 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Afoxolaner impurity 8 (CAS CATO-C4X-31378), a pharmacopoeial impurity reference standard (molecular formula C24H15ClF6N2O4, MW 544.83 g/mol) used for the identification and quantification of trace impurities in APIs.
Afoxolaner impurity 8 (C24H15ClF6N2O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Afoxolaner impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H15ClF6N2O4 |
| Molecular Weight | 544.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Afoxolaner Standards
- Afoxolaner impurity 4 (CAS CATO-C4X-31374)
- Afoxolaner Impurity 14 (CAS 1125726-30-8)
- Afoxolaner Impurity 19 (CAS CATO-C4X-313719)
- Afoxolaner impurity 5 (CAS CATO-C4X-31375)
- Afoxolaner Impurity 17 (CAS CATO-C4X-313717)
- Afoxolaner Impurity 24 (CAS 1352722-19-0)
- Afoxolaner Impurity 15 (CAS CATO-C4X-313715)
- Afoxolaner Impurity 20 (CAS 1125812-60-3)
Recommended Standards
- Tetrabenzylthiuram Disulfide (CAS 10591-85-2)
- 1-(2-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-5-(trifluoromethyl)phenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (CAS 338773-03-8)
- 1,1,3-Tris(2-methyl-4-hydroxy-5-tert-butylphenyl)butane (CAS 1843-03-4)
- (1α,3R,4α,5R)-3,5-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-hydroxy-4-(1H-imidazol-1-ylthioxomethoxy)-cyclohexanecarboxylic Acid Methyl Ester (CAS 139356-32-4)
- Tolvaptan Impurity 101 (CAS CATO-C4X-1955101)
- Progesterone Impurity 57 (CAS 20283-95-8)
- dezocine Impurity 2 (CAS 2889369-01-9)
- 3-Bromo-1,1,1-trifluoropropan-2-ol (CAS 431-34-5)
- 2-Ethynyl-1-methylpiperidine (CAS 51498-56-7)
- 3-Butoxybenzaldehyde (CAS 30609-20-2)
- Sodium 6,6'-((9,10-dioxo-9,10-dihydroanthracene-1,5-diyl)bis(azanediyl))bis(3-methylbenzenesulfonate) (CAS 6408-63-5)
- (2R)-2-[(2-iodo-3-methylphenyl)formamido]propanoic acid (CAS 1604308-75-9)
- Methyl 2,3-di-O-benzyl-α-D-glucopyranoside (CAS 17791-36-5)
- D-Ser39-Tirzepatide (CAS CATO-CPTD788694)
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