Afoxolaner impurity 5 CAS CATO-C4X-31375
| CAS No. | CATO-C4X-31375 |
| Molecular Formula | C24H14ClF9N2O2 |
| Molecular Weight | 568.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Afoxolaner impurity 5 (CAS CATO-C4X-31375, C24H14ClF9N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Afoxolaner impurity 5 (C24H14ClF9N2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 568.82 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C24H14ClF9N2O2 |
| Molecular Weight | 568.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Afoxolaner Standards
- Afoxolaner impurity 4 (CAS CATO-C4X-31374)
- Afoxolaner impurity 8 (CAS CATO-C4X-31378)
- Afoxolaner Impurity 14 (CAS 1125726-30-8)
- Afoxolaner Impurity 19 (CAS CATO-C4X-313719)
- Afoxolaner Impurity 30 (CAS CATO-C4X-313730)
- Afoxolaner Impurity 22 (CAS 1125812-56-7)
- Afoxolaner Impurity 29 (CAS CATO-C4X-313729)
- Afoxolaner Impurity 17 (CAS CATO-C4X-313717)
Recommended Standards
- GSK-8175, >98% (HPLC) (CAS 1423007-82-2)
- (1S,2S)-(+)-[N,N'-Bis(4-bromobenzyl)-1,2-cyclohexanediamino][(2E)-2-buten-1-yl]chlorosilane, min. 98% (CAS 1072220-37-1)
- N,N'-(pentane-1,5-diyl)bis(5-(dimethylamino)naphthalene-1-sulfonamide) (CAS 55521-24-9)
- (1R,2R)-(-)-[N,N'-Bis(4-bromobenzyl)-1,2-cyclohexanediamino][(2E)-2-buten-1-yl]chlorosilane, min. 98% (CAS 804559-39-5)
- Rabeprazole Impurity N10 (CAS 1632219-80-7)
- Erlotinib Impurity 38 (CAS 574738-66-2)
- Ertugliflozin impurity 57 (CAS CATO-C4X-301157)
- 6-HExyloxy-2-hexylsulfanyl-pyrimidin-4-ol (CAS 1892575-76-6)
- 1-(4,6-Dimethoxypyrimidin-2-yl)-3-(3-(trifluoromethyl)phenyl)urea (CAS 190954-81-5)
- 2-(Chloromethyl)-6-(difluoromethyl)-5-fluoropyridine-3-acetic acid (CAS 1807069-22-2)
- (Z)-5-(4-fluorobenzylidene)-3-(4-methylbenzyl)thiazolidine-2,4-dione (CAS 870554-66-8)
- 1-(4-Bromophenyl)-2-phenoxyethanone (CAS 36372-16-4)
- N-[2-(Acetyloxy)-3-chloropropyl]acetamide (CAS 53460-78-9)
- Insulin Degludec Impurity 16 (CAS CATO-C4X-215716)
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