Afoxolaner Impurity 20 CAS 1125812-60-3
| CAS No. | 1125812-60-3 |
| Molecular Formula | C23H14ClF6NO3 |
| Molecular Weight | 501.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Afoxolaner Impurity 20 (CAS 1125812-60-3) is a certified pharmaceutical impurity reference standard with the molecular formula C23H14ClF6NO3 and a molecular weight of 501.81 g/mol.
Based on its molecular formula C23H14ClF6NO3, Afoxolaner Impurity 20 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 501.81 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Afoxolaner Impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H14ClF6NO3 |
| Molecular Weight | 501.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Afoxolaner Standards
- Afoxolaner Impurity 15 (CAS CATO-C4X-313715)
- Afoxolaner Impurity 24 (CAS 1352722-19-0)
- Afoxolaner Impurity 23 (CAS CATO-C4X-313723)
- Afoxolaner Impurity 13 (CAS 1125727-10-7)
- Afoxolaner Impurity 28 (CAS 1308362-48-2)
- Afoxolaner impurity 7 (CAS CATO-C4X-31377)
- Afoxolaner Impurity 18 (CAS CATO-C4X-313718)
- Afoxolaner Impurity 17 (CAS CATO-C4X-313717)
Recommended Standards
- Ethyl 2-((7-chloro-3-(2,4-dichloro-5-isopropoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetate (CAS 339099-23-9)
- (2E)-1-[4-(4-Chlorophenyl)piperazin-1-yl]-3-{4-[(2,4-dichlorophenyl)methoxy]phenyl}prop-2-en-1-one (CAS 477888-83-8)
- (E)-2-((4-chlorobenzyl)thio)quinoline-3-carbaldehyde O-(3,4-dichlorobenzoyl) oxime (CAS 478065-79-1)
- 2-((2-((4-Chlorophenyl)sulfonamido)phenyl)thio)-N-(2,4-dichlorophenyl)acetamide (CAS 477869-03-7)
- Avatrombopag Impurity 60 (CAS CATO-C4X-223460)
- Triptorelin Impurity 40 (CAS CATO-C4X-186240)
- Indocyanine Green Impurity 6 (CAS CATO-C4X-25036)
- 2-Hydroxy-6-methyl-3-(1-(2-phenylhydrazono)ethyl)-4H-pyran-4-one (CAS 137934-93-1)
- 4-Chloro-6-(difluoromethyl)-2-methylpyridine-3-sulfonamide (CAS 1806039-83-7)
- (1S,2S)-Rel-1-amino-2-(trifluoromethyl)cyclopropane-1-carboxylic acid hydrochloride (CAS 1047631-90-2)
- 2-(Difluoromethoxy)benzo[d]oxazole-6-carboxaldehyde (CAS 1806339-89-8)
- 2-Benzyl-1H-benzo[de]isoquinoline-1,3(2H)-dione (CAS 2896-24-4)
- Formaldehyde, polymer with [1,1'-biphenyl]-4-ol (CAS 25820-85-3)
- Valosin Peptide (VQY), porcine (CAS 99510-37-9)
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