Afoxolaner Impurity 28 CAS 1308362-48-2
| CAS No. | 1308362-48-2 |
| Molecular Formula | C22H12ClF6NO3 |
| Molecular Weight | 487.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Afoxolaner Impurity 28.
As a process- or degradation-related impurity, Afoxolaner Impurity 28 (CAS 1308362-48-2, C22H12ClF6NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Afoxolaner Impurity 28 (C22H12ClF6NO3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Afoxolaner Impurity 28 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H12ClF6NO3 |
| Molecular Weight | 487.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Afoxolaner Standards
- Afoxolaner impurity 7 (CAS CATO-C4X-31377)
- Afoxolaner Impurity 18 (CAS CATO-C4X-313718)
- Afoxolaner Impurity 13 (CAS 1125727-10-7)
- Afoxolaner Impurity 23 (CAS CATO-C4X-313723)
- Afoxolaner Impurity 20 (CAS 1125812-60-3)
- Afoxolaner Impurity 16 (CAS 1190862-76-0)
- Afoxolaner impurity 6 (CAS CATO-C4X-31376)
- Afoxolaner Impurity 15 (CAS CATO-C4X-313715)
Recommended Standards
- (E)-3-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)acrylamide (CAS 246022-38-8)
- 1-(4-Methoxyphenyl)-3-(5-phenyl-1-(2,4,6-trichlorophenyl)-1H-pyrazol-4-yl)urea (CAS 477713-92-1)
- Triiodoresorcinol (CAS 58649-90-4)
- 2-[(E)-2-nitro-2-phenyl-ethenyl]thiophene 2-[(E)-2-nitro-2-phenylethenyl]thiophene 5411-70-1 A829972 (CAS 5411-70-1)
- Propofol Impurity 27 (CAS 20170-32-5)
- Glipizide EP Impurity E (CAS 66375-96-0)
- Sitagliptin Impurity 26 (CAS 1402569-71-4)
- 1-((3,4-Dimethylbenzyl)amino)propan-2-ol (CAS 1152926-89-0)
- 2-Hydroxy-3-[3-(trifluoromethyl)phenyl]propanoic Acid (CAS 1537294-67-9)
- 5-(2-Methyl-5-nitrophenyl)furan-2-carbothioamide (CAS 1354749-12-4)
- (Z)-3-((4-Bromophenyl)(4-(methylsulfonyl)phenyl)methylene)dihydrofuran-2(3H)-one (CAS 197438-73-6)
- 1-Bromonaphthalene-D7 (CAS 37621-57-1)
- Oxazolo[4,5-c]quinolin-2(3H)-one (CAS 59851-66-0)
- (Asn5)-Delta-Sleep Inducing Peptide (H-2555.0005) (CAS 80064-67-1)
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