Afoxolaner Impurity 18 CAS CATO-C4X-313718
| CAS No. | CATO-C4X-313718 |
| Molecular Formula | C23H13ClF6O3 |
| Molecular Weight | 486.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Afoxolaner Impurity 18 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Afoxolaner Impurity 18 (CAS CATO-C4X-313718, C23H13ClF6O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Afoxolaner Impurity 18 (C23H13ClF6O3) contains a steroid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C23H13ClF6O3 |
| Molecular Weight | 486.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
Related Afoxolaner Standards
- Afoxolaner Impurity 28 (CAS 1308362-48-2)
- Afoxolaner impurity 7 (CAS CATO-C4X-31377)
- Afoxolaner Impurity 13 (CAS 1125727-10-7)
- Afoxolaner Impurity 23 (CAS CATO-C4X-313723)
- Afoxolaner Impurity 16 (CAS 1190862-76-0)
- Afoxolaner impurity 6 (CAS CATO-C4X-31376)
- Afoxolaner Impurity 20 (CAS 1125812-60-3)
- Afoxolaner Impurity 15 (CAS CATO-C4X-313715)
Recommended Standards
- Thiobis(ethane-2,1-diyl) didodecanoate (CAS 4275-31-4)
- Triethyleneglycoldi-n-dodecylether (CAS 22732-74-7)
- 1,4-didodecyl 2-sulfanylbutanedioate (CAS 63979-81-7)
- Ethyl (2Z)-2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}-3-{[4-(trifluoromethoxy)phenyl]amino}prop-2-enoate (CAS 338966-65-7)
- Bortezomib Impurity 41 (CAS 4664-57-7)
- Ibrutinib Impurity 46 (CAS 330786-24-8)
- Ropivacaine Impurity 17 (CAS CATO-C4X-175317)
- Ethyl 3-(2-chloropyridin-3-yl)-1,2,4-oxadiazole-5-carboxylate (CAS 890095-91-7)
- 2-(4-bromophenyl)-2-oxoethyl 6-cyclopropyl-3-methyl-[1,2]oxazolo[5,4-b]pyridine-4-carboxylate (CAS 1795506-99-8)
- 3-Methyl-1-(2-oxopropoxy)-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one (CAS 307550-58-9)
- 6,6-Difluorospiro[3.3]heptan-2-amine (CAS 1354952-13-8)
- Sunitinib Impurity 38 (CAS 251356-80-6)
- 3-Cyclopropoxy-N-methyl-6-(methylthio)pyridin-2-amine (CAS 1243319-99-4)
- D-[His]1-Semaglutide (CAS CATO-C4X-222652)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com