Resmetirom impurity 81 CAS CATO-C4X-291281
| CAS No. | CATO-C4X-291281 |
| Molecular Formula | C15H16ClN3O3 |
| Molecular Weight | 321.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Resmetirom impurity 81 (CAS CATO-C4X-291281, C15H16ClN3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C15H16ClN3O3, Resmetirom impurity 81 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 321.76 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures Resmetirom impurity 81 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H16ClN3O3 |
| Molecular Weight | 321.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Resmetirom Standards
- Resmetirom impurity 79 (CAS CATO-C4X-291279)
- Resmetirom impurity 63 (CAS CATO-C4X-291263)
- Resmetirom Impurity 92 (CAS CATO-C4X-291292)
- Resmetirom impurity 108 (CAS CATO-C4X-2912108)
- Resmetirom Impurity 41 (CAS 2403724-55-8)
- Resmetirom Impurity 98 (CAS 920509-68-8)
- Resmetirom Impurity 99 (CAS CATO-C4X-291299)
- Resmetirom impurity 83 (CAS CATO-C4X-291283)
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- (1-Benzyl-3-methyl-1h-pyrazol-4-yl)methanamine (CAS 1340310-30-6)
- Methyl 2-(3-ethoxyphenyl)-2-hydroxyacetate (CAS 1250699-70-7)
- (3aS,6aR)-N-Benzyl-1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrol-5-amine dihydrochloride (CAS 2387565-27-5)
- PCB Congener Content Evaluation Revised Mix 1 (CAS CATO-LCHM701260-IO)
- (2R,3S,4R)-5-(1,3-dithian-2-yl)pentane-1,2,3,4-tetraol (CAS 91294-63-2)
- 6-(Methylamino)pyridine-3-carboxylic acid (CAS 262296-02-6)
- Semaglutide impurity 206 (CAS CATO-C4X-2226206)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com