Loratadine EP Impurity 39 CAS 609806-38-4
| CAS No. | 609806-38-4 |
| Molecular Formula | C23H25ClN2O4 |
| Molecular Weight | 428.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Loratadine EP Impurity 39 (CAS 609806-38-4), a pharmacopoeial impurity reference standard (molecular formula C23H25ClN2O4, MW 428.91 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Loratadine EP Impurity 39 (C23H25ClN2O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Loratadine EP Impurity 39 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H25ClN2O4 |
| Molecular Weight | 428.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loratadine Standards
- Loratadine impurity 21 (CAS CATO-C4X-142621)
- Loratadine impurity 22 (CAS CATO-C4X-142622)
- Loratadine Impurity 40 (CAS 609806-37-3)
- Loratadine Impurity 65 (CAS CATO-C4X-142665)
- Loratadine Impurity 81 (CAS CATO-C4X-142681)
- Loratadine Impurity 55 (CAS CATO-C4X-142655)
- Loratadine Impurity 53 (CAS CATO-C4X-142653)
- Loratadine Impurity 43 (CAS CATO-C4X-142643)
Recommended Standards
- Melphalan Impurity 27 (CAS CATO-C4X-198827)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com