Neratinib Impurity 12 CAS 1144516-18-6
| CAS No. | 1144516-18-6 |
| Molecular Formula | C31H32ClN6O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 698.99 g/mol gives Neratinib Impurity 12 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Neratinib Impurity 12 (CAS 1144516-18-6, C31H32ClN6O3I) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Neratinib Impurity 12 (C31H32ClN6O3I) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/iodine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Neratinib Impurity 12 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C31H32ClN6O3 I |
| Molecular Weight | 698.99 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl/I-containing |
| Nitrogen Atoms | 6 |
Related Neratinib Standards
- Neratinib Impurity 10 (CAS 1144516-13-1)
- Neratinib Impurity 14 (CAS 1144516-14-2)
- Neratinib Impurity 21 (CAS 1144516-15-3)
- Neratinib Impurity 11 (CAS 1144516-16-4)
- Neratinib Impurity 18 (CAS 1144516-17-5)
- Neratinib Impurity 17 (CAS 1144516-19-7)
- Neratinib Impurity 2 (CAS 1144516-20-0)
- Neratinib Impurity 13 (CAS 1144516-21-1)
Recommended Standards
- Trelagliptin Impurity 45 (CAS 2565-47-1)
- Clobetasol Propionate EP Impurity F (CAS 2412496-00-3)
- Tolperisone impurity 12 (CAS 59303-41-2)
- 1-Aminohexan-3-ol (CAS 15991-62-5)
- 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)ethan-1-amine hydrochloride (CAS 1177351-21-1)
- (6-(Methylamino)-5-(trifluoromethyl)pyridin-3-yl)boronic acid (CAS 1380593-75-8)
- Zopiclone Impurity 15 (CAS 4180-30-7)
- 2-Chloro-N-(4-(dimethylamino)cyclohexyl)-N-ethylacetamide (CAS 1353988-61-0)
- 5-(Cyclopropylmethyl)-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 2079069-46-6)
- Semaglutide Impurity 4 (CAS CATO-C4X-22264)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com