Crisaborole lmpurity 87 CAS CATO-C4X-202187
| CAS No. | CATO-C4X-202187 |
| Molecular Formula | C14H11NO3 |
| Molecular Weight | 241.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Crisaborole lmpurity 87 (CAS CATO-C4X-202187, C14H11NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Crisaborole lmpurity 87 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 241.24 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Crisaborole lmpurity 87 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H11NO3 |
| Molecular Weight | 241.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole Impurity 7 (CAS 2803552-55-6)
- Crisaborole impurity 161 (CAS CATO-C4X-2021161)
- Crisaborole Impurity 8 (CAS CATO-C4X-20218)
- Crisaborole Impurity 64 (CAS 1160182-44-4)
- Crisaborole lmpurity 78 (CAS 2251695-12-0)
- Crisaborole Hydrate Salt (CAS 2760304-92-3)
- Crisaborole Impurity 10 (CAS 906673-42-5)
- Crisaborole Impurity 11 (CAS 943311-54-4)
Recommended Standards
- Methocarbamol (CAS 532-03-6)
- Pranoprofen Impurity 81 (CAS CATO-C4X-181181)
- Methocarbamol Impurity 1 (CAS 10488-39-8)
- Pranoprofen Impurity 80 (CAS CATO-C4X-181180)
- Teprenone Impurity 13 (CAS CATO-C4X-208113)
- Finerenone Impurity 242 (CAS CATO-C4X-2880242)
- Dapagliflozin Impurity 18 (CAS 461432-22-4)
- N-allyl-4-(benzo[d]thiazol-2-yl)piperidine-1-carboxamide (CAS 478256-95-0)
- 1-(Diethoxyphosphorylmethyl)-2,3,4,5,6-pentafluoro-benzene (CAS 125138-11-6)
- Naftidrofuryl EP Impurity F (CAS 41359-72-2)
- 4-Aminopyridine-2,6-dicarbaldehyde (CAS 1221640-00-1)
- (1-(Pyrrolidin-1-yl)cyclopentyl)methanamine (CAS 917747-55-8)
- 4-((2,5-Difluorophenyl)amino)-4-oxobutanoic acid (CAS 503425-60-3)
- Semaglutide impurity 208 (CAS CATO-C4X-2226208)
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