Nintedanib Impurity 58 CAS 1160293-24-2
| CAS No. | 1160293-24-2 |
| Molecular Formula | C20H16ClNO5 |
| Molecular Weight | 385.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Nintedanib Impurity 58 (CAS 1160293-24-2), a pharmacopoeial impurity reference standard (molecular formula C20H16ClNO5, MW 385.80 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C20H16ClNO5, Nintedanib Impurity 58 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 385.80 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H16ClNO5 |
| Molecular Weight | 385.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Nintedanib Standards
- Nintedanib Impurity 56 (CAS CATO-C4X-181456)
- Nintedanib Impurity 57 (CAS 1174335-83-1)
- Nintedanib Impurity 116 (CAS CATO-C4X-1814116)
- Nintedanib impurity 82 (CAS 2101947-36-6)
- Nintedanib Impurity 133 (CAS CATO-C4X-1814133)
- Nintedanib Impurity N4 (CAS 1987887-92-2)
- Nintedanib Impurity 28 (CAS CATO-C4X-181428)
- Nintedanib Impurity 188 (CAS 2676997-47-8)
Recommended Standards
- (2Z)-2-(Benzenesulfonyl)-1-(2-chloro-4,5-difluorophenyl)-3-(dimethylamino)prop-2-en-1-one (CAS 400088-09-7)
- 1-Benzyl-5-chloro-3-phenyl-2-(trifluoromethyl)-1H-indole (CAS 338966-37-3)
- Lenvatinib Impurity 173 (CAS CATO-C4X-1140173)
- N-(4-(tert-Butyl)phenyl)-3-(5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)acrylamide (CAS 648859-65-8)
- Revefenacin Impurity 14 (CAS 1682660-39-4)
- Neratinib Impurity 31 (CAS CATO-C4X-113431)
- Tedizolid impurity 95 (CAS CATO-C4X-105495)
- N,N,N-Trimethyl-1-(octyloxy)-1-oxodecan-2-aminium bromide (CAS 27587-44-6)
- 2-(Furan-2-yl)-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid (CAS 1240595-44-1)
- 5-tert-Butyl 1-ethyl 3-iodo-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-1,5(4H)-dicarboxylate (CAS 661487-16-7)
- 1-Cyclopropoxy-2,3-diisopropylbenzene (CAS 1243443-60-8)
- 1-(5-Amino-2-methoxypyridin-4-yl)ethan-1-one (CAS 1393558-09-2)
- Methyl 2-(2-amino-3-methoxyphenyl)acetate (CAS 1261855-04-2)
- Liraglutide Impurity 10 TFA Salt (CAS CATO-C4X-199210)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com