Methotrexate Impurity 35 CAS CATO-C4X-115435
| CAS No. | CATO-C4X-115435 |
| Molecular Formula | C14H12N10O3S |
| Molecular Weight | 400.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Methotrexate Impurity 35 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Methotrexate Impurity 35 (CAS CATO-C4X-115435), a pharmacopoeial impurity reference standard (molecular formula C14H12N10O3S, MW 400.38 g/mol) used for the identification and quantification of trace impurities in APIs.
Methotrexate Impurity 35 (C14H12N10O3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C14H12N10O3S |
| Molecular Weight | 400.38 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 10 |
| Sulfur Atoms | 1 |
Related Methotrexate Standards
- Methotrexate Impurity 78 (CAS CATO-C4X-115478)
- Methotrexate impurity 55 (CAS CATO-C4X-115455)
- Methotrexate Impurity 69 (CAS CATO-C4X-115469)
- Methotrexate Impurity 71 (CAS CATO-C4X-115471)
- Methotrexate impurity 54 (CAS CATO-C4X-115454)
- Methotrexate impurity 56 (CAS CATO-C4X-115456)
- Methotrexate Impurity 11 (CAS 143873-72-7)
- Methotrexate EP Impurity B (CAS 54-62-6)
Recommended Standards
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- Daunorubicin EP Impurity E (CAS 28008-51-7)
- Dotinurad Impurity 247 (CAS CATO-C4X-2494247)
- Peridine Impurity 2 (CAS 143900-43-0)
- 【管制禁售】Etomidate EP impurity BHCI (CAS 35944-74-2)
- (3R)-3-Amino-3-phenylpropanenitrile (CAS 1240591-16-5)
- n-(3-Acetylphenyl)-4-(4-chloro-2-methylphenoxy)butanamide (CAS 353467-86-4)
- 3,4-Dibromo-5-methoxyaniline (CAS 95970-21-1)
- (3-Fluoro-2-(pyrrolidin-1-yl)phenyl)methanamine (CAS 1514176-05-6)
- Venetoclax Impurity 138 (CAS CATO-C4X-2495138)
- 5-{[4-chloro-3-(trifluoromethyl)phenyl]methyl}-1,3-thiazol-2-amine (CAS 923732-22-3)
- Ganirelix 1-4 peptide (CAS 208599-57-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com