Fluocinolone Acetonide Impurity 31 CAS 1178-54-7
| CAS No. | 1178-54-7 |
| Molecular Formula | C24H32F2O6 |
| Molecular Weight | 454.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Fluocinolone Acetonide Impurity 31 (CAS 1178-54-7) is a certified pharmaceutical impurity reference standard with the molecular formula C24H32F2O6 and a molecular weight of 454.50 g/mol.
Structurally, Fluocinolone Acetonide Impurity 31 (C24H32F2O6) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 454.50 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Fluocinolone Acetonide Impurity 31 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H32F2O6 |
| Molecular Weight | 454.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Fluocinolone Standards
- Fluocinolone Acetonide Impurity 3 (CAS 4306-83-6)
- Fluocinolone Acetonide Impurity 40 (CAS CATO-C4X-238140)
- Fluocinolone Acetonide-13C3 (CAS 1262192-25-5)
- Fluocinolone Acetonide EP Impurity J (CAS 1361531-95-4)
- Fluocinolone Acetonide EP Impurity K (CAS CATO-C4X-238111)
- Fluocinolone Acetonide (CAS 67-73-2)
- Fluocinolone Acetonide Impurity 38 (CAS CATO-C4X-238138)
- Fluocinolone Acetonide Impurity 41 (CAS CATO-C4X-238141)
Recommended Standards
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