Diphenhydramine EP Impurity C CAS 118-23-0
| CAS No. | 118-23-0 |
| Molecular Formula | C17H20Br |
| Molecular Weight | 334.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Diphenhydramine EP Impurity C (CAS 118-23-0) is a certified pharmaceutical impurity reference standard with the molecular formula C17H20Br and a molecular weight of 334.25 g/mol.
Structurally, Diphenhydramine EP Impurity C (C17H20Br) contains bromine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 7.5, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 334.25 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Diphenhydramine EP Impurity C meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H20Br |
| Molecular Weight | 334.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Br-containing |
Related Diphenhydramine Standards
- Diphenhydramine impurity 18 (CAS 150556-79-9)
- Diphenhydramine impurity 17 (CAS 22808-17-9)
- Diphenhydramine impurity 9 (CAS CATO-C4X-14249)
- Diphenhydramine impurity 14 (CAS CATO-C4X-142414)
- Diphenhydramine N-Oxide (CAS 3922-74-5)
- Diphenhydramine EP Impurity B (CAS 19804-27-4)
- Diphenhydramine (CAS 58-73-1)
- Diphenhydramine EP Impurity A(Dimenhydrinate EP Impurity F) (CAS 17471-10-2)
Recommended Standards
- Nefopam impurity 15 (CAS CATO-C4X-283715)
- Tetraethyl (1-fluoropropane-1,1-diyl)bis(phosphonate) (CAS 1357470-66-6)
- Formoterol impurity 134 (CAS CATO-C4X-1525134)
- 4,4'-Methylenebis(2-(trifluoromethyl)aniline) (CAS 15403-97-1)
- Tucatinib Impurity 39 (CAS CATO-C4X-260539)
- Ozagrel Impurity 15 (CAS 939-57-1)
- Indapamide Impurity 22 (CAS 6872-06-6)
- Isopropyl decanoate (CAS 2311-59-3)
- 2-(o-Tolyl)-2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide (CAS 1031973-44-0)
- 2,5-Dichloro-3,6-difluorothiophenol (CAS 1263377-08-7)
- tert-Butyl 3-(2-mercaptoethyl)piperidine-1-carboxylate (CAS 1420866-00-7)
- N4-cyclopentylpyridine-3,4-diamine (CAS 380605-49-2)
- 2,3-dimethoxypropanenitrile (CAS 64590-97-2)
- Semaglutide Impurity 147 (CAS CATO-C4X-2226147)
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