Diphenhydramine impurity 17 CAS 22808-17-9
| CAS No. | 22808-17-9 |
| Molecular Formula | C17H20ClNO |
| Molecular Weight | 289.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Diphenhydramine impurity 17.
Diphenhydramine impurity 17 (CAS 22808-17-9) is a certified pharmaceutical impurity reference standard with the molecular formula C17H20ClNO and a molecular weight of 289.80 g/mol.
Structurally, Diphenhydramine impurity 17 (C17H20ClNO) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 289.80 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Diphenhydramine impurity 17 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C17H20ClNO |
| Molecular Weight | 289.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Diphenhydramine Standards
- Diphenhydramine impurity 9 (CAS CATO-C4X-14249)
- Diphenhydramine impurity 18 (CAS 150556-79-9)
- Diphenhydramine impurity 14 (CAS CATO-C4X-142414)
- Diphenhydramine N-Oxide (CAS 3922-74-5)
- Diphenhydramine EP Impurity B (CAS 19804-27-4)
- Diphenhydramine (CAS 58-73-1)
- Diphenhydramine EP Impurity C (CAS 118-23-0)
- Diphenhydramine EP Impurity A(Dimenhydrinate EP Impurity F) (CAS 17471-10-2)
Recommended Standards
- Mianserin impurity 55 (CAS CATO-C4X-136955)
- (S)-2-Amino-N-((2-chlorothiazol-5-yl)methyl)-N-isopropyl-3-methylbutanamide (CAS 1354008-84-6)
- 423739-52-0 2-(4-chlorophenyl)-N-(4-ethoxybenzyl)ethanamine DTXSID00365823 (CAS 423739-52-0)
- Chlorphenamine impurity 57 (CAS CATO-C4X-118857)
- Sulfadoxine Impurity 3 (CAS 64704-11-6)
- Epinastine Impurity 57 (CAS CATO-C4X-184057)
- Lifitegrast Impurity 68 (CAS CATO-C4X-240968)
- tert-butyl (3R)-3-[(1H-imidazole-1-carbonyl)amino]pyrrolidine-1-carboxylate (CAS 1186203-58-6)
- 8-Fluoronaphthalen-2-yl 2,2,2-trifluoroacetate (CAS 1956328-10-1)
- Dapoxetine Impurity 43 (CAS 6001-87-2)
- (2-Formyl-4-isopropoxy-5-methoxyphenyl)-acetic acid ethyl ester (CAS 1313365-54-6)
- 2-Amino-1-methyl-1H-imidazole-5-carbonitrile (CAS 155372-97-7)
- 2,5-Dinitropyridine (CAS 15009-92-4)
- D-Ile27-Tirzepatide (CAS CATO-CPTD788907)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com