Dabrafenib Impurity N1 CAS 1195765-47-9
| CAS No. | 1195765-47-9 |
| Molecular Formula | C22H18F3N5O2S2 |
| Molecular Weight | 505.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dabrafenib Impurity N1 is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Dabrafenib Impurity N1 (CAS 1195765-47-9) is a certified pharmaceutical impurity reference standard with the molecular formula C22H18F3N5O2S2 and a molecular weight of 505.54 g/mol.
Dabrafenib Impurity N1 (C22H18F3N5O2S2) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H18F3N5O2S2 |
| Molecular Weight | 505.54 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 2 |
Related Dabrafenib Standards
- Dabrafenib Impurity 17 (CAS 1613724-51-8)
- Dabrafenib Impurity 32 (CAS CATO-C4X-303332)
- Dabrafenib Impurity 22 (CAS CATO-C4X-303322)
- Dabrafenib Impurity 2 (CAS CATO-C4X-30332)
- Dabrafenib Impurity 1 (CAS 2017554-98-0)
- Dabrafenib Impurity 13 (CAS CATO-C4X-303313)
- Dabrafenib Impurity 40 (CAS CATO-C4X-303340)
- Dabrafenib (CAS 1195765-45-7)
Recommended Standards
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- Ethacridine Lactate Impurity 4 (CAS CATO-C4X-26094)
- Prilocaine Impurity 62 (CAS CATO-C4X-193462)
- 2-Cyano-4-(trifluoromethyl)phenylboronic Acid (CAS 1218790-84-1)
- 2-(2-(1H-indol-3-yl)acetyl)-N-benzylhydrazine-1-carbothioamide (CAS 1022401-73-5)
- β-D-Lactopyranosylphenyl isothiocyanate (CAS 96324-93-5)
- 4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}phenyl 4-bromobenzene-1-sulfonate (CAS 338416-31-2)
- 2-(2-Chloroethyl)-5-phenyl-1,3-oxazole (CAS 70680-56-7)
- 1,7-Dimethyl-1H-indazole-4-boronic acid (CAS 2096338-06-4)
- Semaglutide impurity 43 (CAS CATO-C4X-222643)
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