Dabrafenib Impurity 17 CAS 1613724-51-8
| CAS No. | 1613724-51-8 |
| Molecular Formula | C22H16F3N5O2S2 |
| Molecular Weight | 503.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Dabrafenib Impurity 17 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Dabrafenib Impurity 17 (CAS 1613724-51-8, C22H16F3N5O2S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C22H16F3N5O2S2, Dabrafenib Impurity 17 contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 503.52 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H16F3N5O2S2 |
| Molecular Weight | 503.52 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 2 |
Related Dabrafenib Standards
- Dabrafenib Impurity 32 (CAS CATO-C4X-303332)
- Dabrafenib Impurity N1 (CAS 1195765-47-9)
- Dabrafenib Impurity 22 (CAS CATO-C4X-303322)
- Dabrafenib Impurity 2 (CAS CATO-C4X-30332)
- Dabrafenib Impurity 1 (CAS 2017554-98-0)
- Dabrafenib Impurity 13 (CAS CATO-C4X-303313)
- Dabrafenib Impurity 40 (CAS CATO-C4X-303340)
- Dabrafenib (CAS 1195765-45-7)
Recommended Standards
- Fudosteine Impurity 85 (CAS CATO-C4X-144785)
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- Cefoperazone Impurity 41 (CAS CATO-C4X-114941)
- Amorolfine EP Impurity D HCl (CAS 67306-03-0（free base）)
- Mycophenolate Mofetil Impurity 17 (CAS 26644-06-4)
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- Methyl 2-(2-(3,4-dimethoxyphenyl)thiazol-4-yl)acetate (CAS 1081137-63-4)
- Allo-Thr7-Tirzepatide (CAS CATO-CPTD788933)
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