Hydroxychloroquine EP Impurity G Hydrochloride CAS 1198-39-6
| CAS No. | 1198-39-6 |
| Molecular Formula | C9H5Cl2N |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Hydroxychloroquine EP Impurity G Hydrochloride is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Hydroxychloroquine EP Impurity G Hydrochloride (CAS 1198-39-6) is a high-purity analytical reference standard with the molecular formula C9H5Cl2NHCl and a molecular weight of 234.50 g/mol.
The molecular framework of Hydroxychloroquine EP Impurity G Hydrochloride (C9H5Cl2NHCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Hydroxychloroquine EP Impurity G Hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H5Cl2N HCl |
| Molecular Weight | 234.50 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Hydroxychloroquine Standards
- Hydroxychloroquine Impurity 75 (CAS 100713-49-3)
- Hydroxychloroquine EP Impurity B (CAS 103152-84-7)
- Hydroxychloroquine EP Impurity B Hydrogen sulfate (CAS 103152-84-7(free base))
- Hydroxychloroquine EP Impurity E (CAS 10500-64-8)
- Hydroxychloroquine Impurity 32 (CAS 106007-99-2)
- Hydroxychloroquine Impurity 30 (CAS 1077-74-3)
- Hydroxychloroquine Impurity 53 (CAS 109-83-1)
- Hydroxychloroquine D5 (CAS 118-42-3(Unlabelled))
Recommended Standards
- 4-(4-(4-(tert-Butyl)phenyl)-2-hydroxybutoxy)benzoic acid (CAS 96609-16-4)
- (E)-5-bromothiophene-3-carbaldehyde oxime (CAS 18791-96-3)
- Diethyl(2-methoxyethyl)methylammonium Bis(fluorosulfonyl)imide (CAS 1079129-48-8)
- 1-[3-(tert-Butoxy)propyl]piperazine (CAS 1364914-08-8)
- 3-Pentafluoroethylsulfanyl-propionitrile (CAS 1286743-79-0)
- 3-iodo-1-methyl-1H-pyrazole-5-carboxylic acid (CAS 2060062-17-9)
- 1-(tert-Butyl)-4-(2,4-difluorophenyl)pyrrolidine-3-carbonitrile (CAS 1956335-77-5)
- 3-(4-Benzoylphenyl)propanoic acid (CAS 71388-83-5)
- 5-Bromo-2-(dimethylamino)benzaldehyde (CAS 171881-36-0)
- A-18-F-NH2; Morphine Modulating Neuropeptide (CAS 99588-52-0)
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