Betamethasone impurity 55 CAS 1202002-02-5

Description

The occurrence of Betamethasone impurity 55 is closely related to a flavonoid core, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

CATO supplies Betamethasone impurity 55 (CAS 1202002-02-5), a pharmacopoeial impurity reference standard (molecular formula C22H30FO8P, MW 472.44 g/mol) used for the identification and quantification of trace impurities in APIs.

The molecular framework of Betamethasone impurity 55 (C22H30FO8P) is characterized by a flavonoid core, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), Betamethasone impurity 55 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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