Dolutegravir Impurity 22 CAS 1206102-11-5
| CAS No. | 1206102-11-5 |
| Molecular Formula | C27H25F2N3O5 |
| Molecular Weight | 509.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Dolutegravir Impurity 22 (CAS 1206102-11-5, C27H25F2N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Dolutegravir Impurity 22 (C27H25F2N3O5) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H25F2N3O5 |
| Molecular Weight | 509.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Dolutegravir Standards
- Dolutegravir Impurity 17 (CAS CATO-C4X-162017)
- Dolutegravir Impurity 30 (CAS CATO-C4X-162030)
- Dolutegravir Impurity 66 (CAS CATO-C4X-162066)
- Dolutegravir Impurity 33 (CAS CATO-C4X-162033)
- Dolutegravir Impurity 26 (CAS CATO-C4X-162026)
- Dolutegravir Impurity 10 (CAS CATO-C4X-162010)
- Dolutegravir Impurity 21 (CAS CATO-C4X-162021)
- Dolutegravir Impurity 61 (CAS CATO-C4X-162061)
Recommended Standards
- 4-(2-Hydroxyethyl)-5-methyl-2-phenyl-1-((2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)sulfonyl)-1,2-dihydro-3H-pyrazol-3-one (CAS 861207-34-3)
- 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-[2-[(2-hydroxybenzoyl)amino]ethyl] Ester (CAS 92565-34-9)
- Cefuroxime Impurity 76 (CAS CATO-C4X-124576)
- Methyl 2-((11aS)-5-(4-(methoxycarbonyl)phenyl)-1,3-dioxo-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indol-2(3H)-yl)benzoate (CAS 957010-04-7)
- Encorafenib Impurity 13 (CAS CATO-C4X-324913)
- Tirofiban Impurity 100 (CAS CATO-C4X-1254100)
- Ilaprazole Impurity 165 (CAS 253345-81-2)
- 4-Amino-1-ethyl-N-((tetrahydrofuran-2-yl)methyl)-1H-pyrazole-5-carboxamide (CAS 1006484-76-9)
- 3-(Piperidin-1-yl)pyridin-2-amine (CAS 1286273-41-3)
- Methyl 3-amino-5-bromo-4-methoxybenzoate (CAS 40258-74-0)
- 5-Amino-2,4-dichloropyrimidine (CAS 5177-27-5)
- Ethyl indolizine-1-carboxylate (CAS 93476-46-1)
- 7-Chloro-2-methyl-1,3-diphenyl-2,3-dihydro-1H-imidazo[4,5-b]quinoxalin-4-ium 4-methylbenzenesulfonate (CAS 25983-11-3)
- [Glu]17-Semaglutide (CAS CATO-CPTD788604)
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