Encorafenib Impurity 13 CAS CATO-C4X-324913
| CAS No. | CATO-C4X-324913 |
| Molecular Formula | C18H18ClFN6O3S |
| Molecular Weight | 452.89 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Encorafenib Impurity 13 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Encorafenib Impurity 13 (CAS CATO-C4X-324913) is a certified pharmaceutical impurity reference standard with the molecular formula C18H18ClFN6O3S and a molecular weight of 452.89 g/mol.
The molecular framework of Encorafenib Impurity 13 (C18H18ClFN6O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H18ClFN6O3S |
| Molecular Weight | 452.89 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Encorafenib Standards
- Encorafenib Impurity 15 (CAS CATO-C4X-324915)
- Encorafenib Impurity 9 (CAS CATO-C4X-32499)
- Encorafenib Impurity 11 (CAS CATO-C4X-32411)
- Encorafenib Impurity 10 (CAS 1269440-78-9)
- Encorafenib Impurity 18 (CAS CATO-C4X-324918)
- Encorafenib Impurity 8 (CAS CATO-C4X-32498)
- Encorafenib Impurity 3 (CAS CATO-C4X-32493)
- Encorafenib Impurity 6 (CAS CATO-C4X-32496)
Recommended Standards
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- Elvitegravir-d6 (Major) (CAS 1131640-69-1)
- Dobutamine Impurity 44 HCl (CAS 63434-00-4（Free Base）)
- Relugolix Impurity 33 (CAS CATO-C4X-242933)
- Celecoxib Impurity 45 (CAS 90824-33-2)
- 3-(2-Bromophenyl)-1,1,1-trifluoropropan-2-one (CAS 898787-57-0)
- (E)-5-chloropenta-1,3-diene (CAS 40596-30-3)
- 4,4'-Bis(4-(4-phenoxyphenoxy)phenoxy)-1,1'-biphenyl (CAS 62203-77-4)
- 2,4-Diphenyl-6-(4´-methoxyphenyl)pyrylium perchlorate (CAS 47501-44-0)
- 6-(1,2,3-Triazol-1-yl)-1-hexanol (CAS 1793088-06-8)
- methyl 2-(4-chloro-2-vinylphenyl)acetate (CAS 936098-40-7)
- Semaglutide impurity 276 (CAS CATO-C4X-2226276)
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