Dolutegravir Impurity 10 CAS CATO-C4X-162010
| CAS No. | CATO-C4X-162010 |
| Molecular Formula | C27H24F4N4O4 |
| Molecular Weight | 544.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Dolutegravir Impurity 10 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Dolutegravir Impurity 10 (CAS CATO-C4X-162010, C27H24F4N4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C27H24F4N4O4, Dolutegravir Impurity 10 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 544.50 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C27H24F4N4O4 |
| Molecular Weight | 544.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Dolutegravir Standards
- Dolutegravir Impurity 26 (CAS CATO-C4X-162026)
- Dolutegravir Impurity 32 (CAS CATO-C4X-162032)
- Dolutegravir Impurity 17 (CAS CATO-C4X-162017)
- Dolutegravir Impurity 30 (CAS CATO-C4X-162030)
- Dolutegravir Impurity 22 (CAS 1206102-11-5)
- Dolutegravir Impurity 66 (CAS CATO-C4X-162066)
- Dolutegravir Impurity 16 (CAS 2244161-73-5)
- Dolutegravir Impurity 33 (CAS CATO-C4X-162033)
Recommended Standards
- Methyl 1-((2-Benzyloxycarbonxyl)phenyl)-2,3,4-tri-O-acetyl-β-D-glucopyranuronate (CAS 221287-88-3)
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- Curcumin Glucuronide (CAS 227466-72-0)
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- Allopurinol impurity 22 (CAS CATO-C4X-145822)
- Bambuterol Impurity 11 (CAS CATO-C4X-274611)
- Relugolix Impurity 188 (CAS CATO-C4X-2429188)
- Poly-L-lysine hydrochloride (15-30 kDa) (CAS 26124-78-7)
- 6-Bromo-4-methoxypicolinaldehyde (CAS 1060805-07-3)
- Sofosbuvir Impurity 112 (CAS 62062-65-1)
- (2-Chloro-4-fluorobenzyl)(phenyl)sulfane (CAS 1443313-82-3)
- 2-(Dihydro-2H-pyran-4(3H)-ylidene)malononitrile (CAS 62702-83-4)
- ((2S,4S)-4-Acetoxy-5-oxotetrahydrofuran-2-yl)methyl acetate (CAS 79580-65-7)
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