Dolutegravir Impurity 66 CAS CATO-C4X-162066
| CAS No. | CATO-C4X-162066 |
| Molecular Formula | C24H19F4N3O5 |
| Molecular Weight | 505.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Dolutegravir Impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Dolutegravir Impurity 66 (CAS CATO-C4X-162066), a pharmacopoeial impurity reference standard (molecular formula C24H19F4N3O5, MW 505.42 g/mol) used for the identification and quantification of trace impurities in APIs.
Dolutegravir Impurity 66 (C24H19F4N3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C24H19F4N3O5 |
| Molecular Weight | 505.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Dolutegravir Standards
- Dolutegravir Impurity 22 (CAS 1206102-11-5)
- Dolutegravir Impurity 33 (CAS CATO-C4X-162033)
- Dolutegravir Impurity 17 (CAS CATO-C4X-162017)
- Dolutegravir Impurity 30 (CAS CATO-C4X-162030)
- Dolutegravir Impurity 26 (CAS CATO-C4X-162026)
- Dolutegravir Impurity 10 (CAS CATO-C4X-162010)
- Dolutegravir Impurity 21 (CAS CATO-C4X-162021)
- Dolutegravir Impurity 61 (CAS CATO-C4X-162061)
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Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com