Haloperidol impurity 02 CAS 121751-79-9
| CAS No. | 121751-79-9 |
| Molecular Formula | C11H14ClNO |
| Molecular Weight | 211.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Haloperidol impurity 02.
Haloperidol impurity 02 (CAS 121751-79-9) is a certified pharmaceutical impurity reference standard with the molecular formula C11H14ClNO and a molecular weight of 211.69 g/mol.
The molecular framework of Haloperidol impurity 02 (C11H14ClNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Haloperidol impurity 02 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H14ClNO |
| Molecular Weight | 211.69 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Haloperidol Standards
- Haloperidol Impurity 19 (CAS 71501-46-7)
- Haloperidol Impurity 13 (CAS 17135-46-5)
- Haloperidol Impurity 18 (CAS 2823-19-0)
- Haloperidol Impurity 21 (CAS 3874-54-2)
- Haloperidol impurity 24 (CAS 3110-52-9)
- Haloperidol Impurity N1 (CAS 939-52-6)
- Haloperidol Impurity 23 (CAS 73206-04-9)
- Haloperidol Impurity 37 (CAS 84819-46-5)
Recommended Standards
- (S)-2-(3-chloro-4-methoxyphenyl)pyrrolidine (CAS 1213515-69-5)
- ((3R,4S)-4-(4-chlorophenyl)pyrrolidin-3-yl)methanol (CAS 1217684-40-6)
- (S)-(3-chloro-4-methoxyphenyl)(cyclopropyl)methanamine (CAS 1213489-83-8)
- 3-(2-Chloro-4,6-dimethylphenoxy)azetidine (CAS 1219960-77-6)
- Betahistine impurity 36 HCl (CAS 58379-60-5(free base))
- Felodipine Impurity 11 (CAS 150131-21-8)
- Trimetazidine impurity 32 (CAS CATO-C4X-180332)
- 1-{[1-(4-chlorobenzenesulfonyl)-4-hydroxypiperidin-4-yl]methyl}piperidin-4-one (CAS 861212-73-9)
- 3-(Trifluoromethyl)phenyl 2-(N-phenylbenzenesulfonamido)acetate (CAS 343373-54-6)
- (5S,8E,10E,12R)-5,12-Dihydroxy-8,10-pentadecadiene-6,14-diynoic Acid 1-Methylethyl Ester (CAS 1251537-11-7)
- 3-Bromo-5-chloro-4-methoxypyridine (CAS 1214362-58-9)
- 4-[(4-Bromo-3-methylphenoxy)methyl]piperidinehydrochloride (CAS 1220032-80-3)
- Cupric L-(+)-tartrate trihydrate (CAS 5893-71-0)
- Semaglutide impurity 57 (CAS 2773558-06-6)
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