Haloperidol Impurity 21 CAS 3874-54-2
| CAS No. | 3874-54-2 |
| Molecular Formula | C10H10ClFO |
| Molecular Weight | 200.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Haloperidol Impurity 21 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Haloperidol Impurity 21 (CAS 3874-54-2) is a certified pharmaceutical impurity reference standard with the molecular formula C10H10ClFO and a molecular weight of 200.64 g/mol.
Haloperidol Impurity 21 (C10H10ClFO) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H10ClFO |
| Molecular Weight | 200.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F/Cl-containing |
Related Haloperidol Standards
- Haloperidol Impurity 18 (CAS 2823-19-0)
- Haloperidol impurity 24 (CAS 3110-52-9)
- Haloperidol impurity 02 (CAS 121751-79-9)
- Haloperidol Impurity 19 (CAS 71501-46-7)
- Haloperidol Impurity 13 (CAS 17135-46-5)
- Haloperidol Impurity N1 (CAS 939-52-6)
- Haloperidol Impurity 23 (CAS 73206-04-9)
- Haloperidol Impurity 37 (CAS 84819-46-5)
Recommended Standards
- propan-2-yl 2-(chlorosulfonyl)acetate (CAS 303153-12-0)
- 3-Chloro-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine (CAS 100859-88-9)
- Methyl 4-chlorosulfonyl-butanoate (CAS 81926-28-5)
- 2-Chloro-5-methoxy-[1,3]thiazolo[5,4-b]pyridine (CAS 1196154-04-7)
- Ibandronic Impurity 2 (CAS 625120-81-2)
- Daptomycin Impurity 37 (CAS CATO-C4X-137837)
- Atorvastatin EP Impurity D (CAS 148146-51-4)
- N-(4-Ethylphenyl)-N-[(4-methylphenyl)sulfonyl]glycine (CAS 884987-72-8)
- N-Methyl-D-glucamine HCI (CAS 35564-86-4)
- (S)-Oteseconazole (CAS 1446515-60-1)
- N-benzyl-4-(3-methylbutanoyl)-1H-pyrrole-2-carboxamide (CAS 478259-14-2)
- (S)-Methyl 2-amino-3-(3,4-dimethoxyphenyl)propanoate hydrochloride (CAS 70494-48-3)
- 6-Amino-3-(difluoromethyl)-5-nitropicolinoyl chloride (CAS 1805224-94-5)
- Semaglutide Impurity 138 (CAS CATO-C4X-2226138)
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