Haloperidol Impurity 37 CAS 84819-46-5
| CAS No. | 84819-46-5 |
| Molecular Formula | C10H9FO2 |
| Molecular Weight | 180.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Haloperidol Impurity 37 (CAS 84819-46-5, C10H9FO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Haloperidol Impurity 37 (C10H9FO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 180.18 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H9FO2 |
| Molecular Weight | 180.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | F-containing |
Related Haloperidol Standards
- Haloperidol Impurity 23 (CAS 73206-04-9)
- Haloperidol Impurity N1 (CAS 939-52-6)
- Haloperidol Impurity 16 (CAS 40807-61-2)
- Haloperidol Impurity 19 (CAS 772-31-6)
- Haloperidol Impurity 18 (CAS 2823-19-0)
- Haloperidol Impurity 21 (CAS 3874-54-2)
- Haloperidol impurity 24 (CAS 3110-52-9)
- Haloperidol Impurity N10 (CAS 403-43-0)
Recommended Standards
- 2-fluoro-4-(oxetan-3-yl)benzaldehyde (CAS CATO-C3D-262183)
- Aztreonam Impurity 1 (CAS 80082-65-1)
- 1-(2-fluorophenyl)cyclopropane-1-carboxylic acid 1-Carboxy-1-(2-fluorophenyl)cyclopropane 306298-00-0 (CAS 306298-00-0)
- Aztreonam Impurity 34 (CAS 80582-09-8)
- Rivaroxaban Impurity N6 (CAS 5466-93-3)
- Gefitinib Impurity 8 (CAS 847949-49-9)
- Avatrombopag Impurity 118 (CAS CATO-C4X-2234118)
- 1-(2-Ethyl-1H-imidazol-1-yl)propan-2-one (CAS 1015846-63-5)
- Methyl 2-(ethylamino)heptanoate (CAS 1218133-80-2)
- (E)-1-(2-hydroxy-5-nitrophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one (CAS 173959-42-7)
- 3-Chloro-2-(3-(1-(phenylsulfonyl)-1H-pyrazol-3-yl)phenoxy)-5-(trifluoromethyl)pyridine (CAS 321385-86-8)
- 4,6-Dimethyl-2-(pyrrolidin-1-yl)pyridine-3-carbothioamide (CAS 1193387-78-8)
- Angiotensinogen (1-14), porcine (CAS 20845-02-7)
- Semaglutide Impurity 16 (CAS CATO-C4X-222616)
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