Aprepitant Impurity 18 CAS CATO-C4X-114118
| CAS No. | CATO-C4X-114118 |
| Molecular Formula | C20H18F7NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Aprepitant Impurity 18 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Aprepitant Impurity 18 (CAS CATO-C4X-114118) is a certified pharmaceutical impurity reference standard with the molecular formula C20H18F7NO2HCl and a molecular weight of 473.81 g/mol.
Aprepitant Impurity 18 (C20H18F7NO2HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Aprepitant Impurity 18 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H18F7NO2 HCl |
| Molecular Weight | 473.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant D4 (CAS 1133387-60-6)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Aprepitant-13C2,d2 (Major) (CAS 1217676-37-3)
- Aprepitant Impurity 7 (CAS 1242175-34-3)
- Aprepitant Impurity 5 (CAS 1242175-40-1)
- Aprepitant Impurity 33 (CAS 1265177-56-7)
- Aprepitant Impurity 38 (CAS 127852-28-2)
Recommended Standards
- Lasmiditan Impurity 11 (CAS CATO-C4X-247811)
- Fosaprepitant Impurity 18 (CAS 252742-72-6)
- Evocalcet Impurity 32 (CAS CATO-C4X-248532)
- 5-(o-Tolyl)isoxazole (CAS 918884-77-2)
- Ilaprazole Impurity N1 (CAS 84445-90-9)
- 1-([1,1'-Biphenyl]-4-yl)-3-((4-(trifluoromethyl)phenyl)amino)propan-1-one (CAS 883793-80-4)
- N-(3,3-dimethylbutan-2-yl)-2,2-dimethylthietan-3-amine (CAS 1858613-62-3)
- 3,4-Dihydroxyaniline Hydrobromide (CAS 158627-59-9)
- 2-(Cyclohexyloxy)pyridin-3-amine (CAS 147143-56-4)
- D-[Asp]9-Semaglutide (CAS CATO-CPTD788631)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com