Chlorpromazine EP Impurity D CAS 1225-64-5
| CAS No. | 1225-64-5 |
| Molecular Formula | C16H17ClN2S |
| Molecular Weight | 304.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Chlorpromazine EP Impurity D (C16H17ClN2S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Chlorpromazine EP Impurity D (CAS 1225-64-5) is a certified pharmaceutical impurity reference standard with the molecular formula C16H17ClN2S and a molecular weight of 304.84 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Chlorpromazine EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H17ClN2S |
| Molecular Weight | 304.84 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chlorpromazine Standards
- Chlorpromazine (CAS 50-53-3)
- Chlorpromazine Impurity 8 (CAS 58-40-2)
- Chlorpromazine Impurity 20 (CAS CATO-C4X-142120)
- Chlorpromazine EP Impurity A (CAS 969-99-3)
- Chlorpromazine Impurity 12 (CAS 1672-76-0)
- Chlorpromazine Impurity 6 (CAS 1730-46-7)
- Chlorpromazine N-Oxide Sulfoxide (CAS 10404-90-7)
- Chlorpromazine Sulfone (CAS 4337-86-4)
Recommended Standards
- 7-chloro-3-[(oxolan-2-yl)methyl]-2-sulfanyl-3,4-dihydroquinazolin-4-one (CAS 851169-53-4)
- (R)-2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethanol (CAS 1395078-43-9)
- 4-Chloro-N-(3-(dimethylamino)propyl)-2,5-dimethylbenzenesulfonamide (CAS 899247-65-5)
- Venetoclax Impurity 133 (CAS CATO-C4X-2495133)
- Relugoli Impurity 138 (CAS CATO-C4X-2429138)
- Lifitegrast Impurity 111 (CAS CATO-C4X-2409111)
- Phloroglucinol impurity 44 (CAS 23957-21-3)
- ((1S,4R)-3,3-Dimethylbicyclo[2.2.1]heptan-2-yl)methanol (CAS 684284-13-7)
- Upadacitinib Impurity 18 (CAS 1428243-24-6)
- (S)-4,4-difluoro-5-oxopyrrolidine-2-carboxylic acid (CAS 1932456-62-6)
- (2S,4R)-1-(tert-Butoxycarbonyl)-4-(3-chlorobenzyl)pyrrolidine-2-carboxylic acid (CAS 959576-36-4)
- (R)-3-(4-Nitrophenoxy)pyrrolidine hydrochloride (CAS 1286208-84-1)
- N-[(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)methylene](4-methylphenyl)methanamine (CAS 241132-52-5)
- Semaglutide Impurity 246 (CAS CATO-C4X-2226246)
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