Pioglitazone impurity 01 CAS 1229114-67-3
| CAS No. | 1229114-67-3 |
| Molecular Formula | C36H40N2O6S2 |
| Molecular Weight | 660.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C36H40N2O6S2, Pioglitazone impurity 01 contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 660.84 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Pioglitazone impurity 01 (CAS 1229114-67-3, C36H40N2O6S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C36H40N2O6S2 |
| Molecular Weight | 660.84 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related Pioglitazone Standards
- Pioglitazone EP Impurity G (CAS 952187-99-4)
- Pioglitazone Thiazolidinedione Ring-opened N-β-D-Glucuronide (CAS 1296832-76-2)
- Pioglitazone N-beta-D-Glucuronide (Mixture of Diastereomers) (CAS 1296832-75-1)
- Pioglitazone impurity 29 (CAS CATO-C4X-138329)
- Pioglitazone EP Impurity C (CAS 952188-00-0)
- Pioglitazone impurity 52 (CAS CATO-C4X-138352)
- Pioglitazone impurity 57 (CAS 1147527-36-3)
- Pioglitazone Impurity 2 (CAS CATO-C4X-13832)
Recommended Standards
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- Finerenone Impurity 267 (CAS CATO-C4X-2880267)
- Mianserin Impurity 121 (CAS CATO-C4X-1369121)
- Pitolisant impurity 29 (CAS CATO-C4X-252029)
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- 8-methyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one (CAS 110766-86-4)
- Ethyl (2R,6R)-6-methyl-4-oxopiperidine-2-carboxylate (CAS 315198-13-1)
- 4-Chlorothiazol-2-amine hydrochloride (CAS 878744-05-9)
- Mast Cell Degranulating (MCD) Peptide HR-2 (CAS 80388-04-1)
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