Nintedanib Impurity 67 CAS 40872-87-5
| CAS No. | 40872-87-5 |
| Molecular Formula | C8H8ClNO2 |
| Molecular Weight | 185.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Nintedanib Impurity 67 (CAS 40872-87-5, C8H8ClNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Nintedanib Impurity 67 (C8H8ClNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Nintedanib Impurity 67 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H8ClNO2 |
| Molecular Weight | 185.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Nintedanib Standards
- Nintedanib Impurity 184 (CAS 873376-89-7)
- Nintedanib Impurity 39 (CAS 3395-81-1)
- Nintedanib Impurity 44 (CAS 3395-80-0)
- Nintedanib Impurity 45 (CAS 70380-66-4)
- Nintedanib Impurity 38 (CAS 58378-33-9)
- Nintedanib Impurity 42 (CAS 2186-92-7)
- Nintedanib Impurity 43 (CAS 59276-28-7)
- Nintedanib Impurity 66 (CAS 707-07-3)
Recommended Standards
- Paracetamol EP Impurity C (CAS 3964-54-3)
- Pyridoxine impurity 89 (CAS CATO-C4X-187789)
- Clopidogrel Impurity 68 (CAS 6212-33-5)
- Ruxolitinib Impurity 46 (CAS 1236033-25-2)
- Remimazolam Impurity 16 (CAS CATO-C4X-282316)
- Apalutamide Impurity 6 (CAS 1332391-11-3)
- Ticagrelor Impurity 140 (CAS CATO-C4X-1093140)
- Lusutrombopag Impurity 15 (CAS CATO-C4X-208415)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com