Dasatinib Impurity 43 CAS 1245157-85-0
| CAS No. | 1245157-85-0 |
| Molecular Formula | C24H28ClN7O3S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Dasatinib Impurity 43.
As a process- or degradation-related impurity, Dasatinib Impurity 43 (CAS 1245157-85-0, C24H28ClN7O3SC2HF3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Dasatinib Impurity 43 (C24H28ClN7O3SC2HF3O2) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 644.07 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Dasatinib Impurity 43 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H28ClN7O3S C2HF3O2 |
| Molecular Weight | 644.07 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 1 |
Related Dasatinib Standards
Recommended Standards
- Dapagliflozin Impurity N3 (CAS 2452300-92-2)
- Tenofovir Impurity 34 (CAS CATO-C4X-107634)
- Mirabegron EP Impurity D (CAS 2489747-26-2)
- 2-(Chloromethyl)-5-(4-methoxy-3-methylphenyl)-1,3,4-oxadiazole (CAS 1086398-45-9)
- 2-(2-((Tert-butyldimethylsilyl)oxy)phenyl)-2-methylpropanal (CAS 2338684-90-3)
- 1-Oxa-9-azaspiro[5.5]undecan-5-ol (CAS 174469-91-1)
- 2-(4-(tert-Butyl)-1H-imidazol-2-yl)morpholine (CAS 1707679-62-6)
- Prednisolone impurity 66 (CAS 137759-50-3)
- N-(4-Fluorophenyl)-4-phenylpiperazine-1-carboxamide (CAS 84882-89-3)
- Semaglutide impurity 85 (CAS CATO-C4X-222685)
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