Ivabradine Impurity 4 CAS 1246638-08-3
| CAS No. | 1246638-08-3 |
| Molecular Formula | C26H34N2O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 491.03 g/mol gives Ivabradine Impurity 4 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Ivabradine Impurity 4 (CAS 1246638-08-3), a pharmacopoeial impurity reference standard (molecular formula C26H34N2O5HCl, MW 491.03 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Ivabradine Impurity 4 (C26H34N2O5HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H34N2O5 HCl |
| Molecular Weight | 491.03 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Ivabradine Standards
- Ivabradine Impurity 25 HCl (CAS 1132079-01-6)
- Ivabradine impurity 90 (CAS 1132667-04-9)
- Ivabradine Impurity 9 (CAS 1204612-29-2)
- Ivabradine Impurity 28 (CAS 1206230-28-5)
- Ivabradine-d3 Hydrochloride (CAS 1217809-61-4)
- Ivabradine impurity 86 (CAS 1220993-44-1)
- Ivabradine Impurity 20 (CAS 1235547-06-4)
- Ivabradine Impurity 21 (CAS 1235547-07-5)
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- 1-(3-(Trifluoromethyl)cyclobutyl)ethan-1-ol (CAS 2091774-79-5)
- Semaglutide impurity 93 (CAS CATO-C4X-222693)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com