Nintedanib Impurity 75 CAS 1253768-91-0
| CAS No. | 1253768-91-0 |
| Molecular Formula | C16H11NO4 |
| Molecular Weight | 281.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Nintedanib Impurity 75 (C16H11NO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Nintedanib Impurity 75 (CAS 1253768-91-0) is a certified pharmaceutical impurity reference standard with the molecular formula C16H11NO4 and a molecular weight of 281.26 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H11NO4 |
| Molecular Weight | 281.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 1 |
Related Nintedanib Standards
- Nintedanib Impurity 108 (CAS CATO-C4X-1814110)
- Nintedanib Impurity 118 (CAS CATO-C4X-1814118)
- Nintedanib Impurity 102 (CAS CATO-C4X-1814102)
- Nintedanib Impurity 9 (CAS 1038972-16-5)
- Nintedanib Impurity 127 (CAS CATO-C4X-1814127)
- Nintedanib Impurity 140 (CAS CATO-C4X-1814140)
- Nintedanib Impurity 150 (CAS CATO-C4X-1814150)
- Nintedanib Impurity 151 (CAS CATO-C4X-1814151)
Recommended Standards
- Roxadustat Impurity 129 (CAS CATO-C4X-2213129)
- Candesartan Impurity 1 (CAS CATO-C4X-15721)
- Roxadustat Impurity 18 (CAS 2376195-48-9)
- Metoclopramide Impurity 27 (CAS CATO-C4X-141527)
- Mivacurium chloride Impurity 37 (CAS 91248-14-5)
- (Z)-Ceftizoxime Oxide Impurity 2 (CAS 79226-66-7)
- Nicardipine EP Impurity A HCl (CAS 1216817-27-4)
- (S)-4-Nitrophenyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-methylpentanoate (CAS 71989-25-8)
- 2-(S)-(3,5-Bis(4-(trifluoromethyl)phenyl)phenyl)-4-methylpentanoic Acid (CAS 1146594-87-7)
- Ethyl Piperidin-4-ylacetate (CAS 59184-90-6)
- 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)triazole (CAS 1657004-85-7)
- N-2-Naphthyl-3-oxo-3-phenylpropanamide (CAS 17738-45-3)
- 12-(4-Chlorophenyl)-9,9-dimethyl-8,9,10,12-tetrahydrobenzo[a]acridin-11(7H)-one (CAS 326903-19-9)
- Characteristic MSH-Tetrapeptide (CAS 4289-02-5)
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