Nintedanib Impurity 151 CAS CATO-C4X-1814151
| CAS No. | CATO-C4X-1814151 |
| Molecular Formula | C10H11Cl3O3 |
| Molecular Weight | 285.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 285.55 g/mol gives Nintedanib Impurity 151 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Nintedanib Impurity 151 (CAS CATO-C4X-1814151) is a certified pharmaceutical impurity reference standard with the molecular formula C10H11Cl3O3 and a molecular weight of 285.55 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Nintedanib Impurity 151 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 285.55 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11Cl3O3 |
| Molecular Weight | 285.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Nintedanib Standards
- Nintedanib Impurity 140 (CAS CATO-C4X-1814140)
- Nintedanib Impurity 150 (CAS CATO-C4X-1814150)
- Nintedanib Impurity 152 (CAS CATO-C4X-1814152)
- Nintedanib Impurity 153 (CAS CATO-C4X-1814153)
- Nintedanib Impurity 124 (CAS CATO-C4X-1814124)
- Nintedanib Nintedanib Impurity 88 (CAS CATO-C4X-181488)
- Nintedanib Impurity 108 (CAS CATO-C4X-1814110)
- Nintedanib Impurity 75 (CAS 1253768-91-0)
Recommended Standards
- 5-Bromo-6-chloro-N-methylpyridine-3-sulfonamide (CAS 622814-92-0)
- 6-Bromo-1-chloro-2-ethoxynaphthalene (CAS 1394291-31-6)
- 5-Bromo-4-chloro-6-methyl-2-(methylsulfonyl)pyrimidine (CAS 98141-98-1)
- 3-Chloro-2,6-dinitro-4-(trifluoromethyl)benzenamine (CAS 959235-57-5)
- Cyclobenzaprine Impurity 4 (CAS 1971-54-6)
- Doxapram Impurity 6 (CAS CATO-C4X-19736)
- Carbocisteine Impurity 41 (CAS CATO-C4X-201041)
- 1-(2-Chloroethyl)-4-methylpiperidine hydrochloride (CAS 56859-59-7)
- Methyl 2-(4-acetylpiperidin-1-yl)acetate (CAS 1340113-79-2)
- 4-{[5-(2,4-dichlorophenyl)furan-2-yl]methyl}-1,2-dihydrophthalazin-1-one (CAS 338756-74-4)
- (5-(3,4,5-Trimethoxyphenyl)-1H-1,2,4-triazol-3-yl)methanol (CAS 1547375-80-3)
- pentacyclo[5.4.0.0²,⁶.0³,¹⁰.0⁵,⁹]undecane-8,11-dione (CAS 2958-72-7)
- Isochamaejasmin (CAS 93859-63-3)
- Semaglutide impurity 42 (CAS CATO-C4X-222642)
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