Nintedanib Impurity 140 CAS CATO-C4X-1814140
| CAS No. | CATO-C4X-1814140 |
| Molecular Formula | C10H11Cl3O3 |
| Molecular Weight | 285.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Nintedanib Impurity 140 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Nintedanib Impurity 140 (CAS CATO-C4X-1814140, C10H11Cl3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Nintedanib Impurity 140 (C10H11Cl3O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H11Cl3O3 |
| Molecular Weight | 285.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Nintedanib Standards
- Nintedanib Impurity 150 (CAS CATO-C4X-1814150)
- Nintedanib Impurity 151 (CAS CATO-C4X-1814151)
- Nintedanib Impurity 152 (CAS CATO-C4X-1814152)
- Nintedanib Impurity 153 (CAS CATO-C4X-1814153)
- Nintedanib Impurity 124 (CAS CATO-C4X-1814124)
- Nintedanib Nintedanib Impurity 88 (CAS CATO-C4X-181488)
- Nintedanib Impurity 108 (CAS CATO-C4X-1814110)
- Nintedanib Impurity 75 (CAS 1253768-91-0)
Recommended Standards
- 5-Bromo-6-chloro-N-methylpyridine-3-sulfonamide (CAS 622814-92-0)
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- 3,3,4-Trichlorobenzophenone (CAS 812684-89-2)
- 2-Chloroethyl (5-bromothiazol-2-yl)carbamate (CAS 353265-54-0)
- Valaciclovir EP Impurity R (CAS 142963-59-5)
- Vazegepant Impurity 44 (CAS CATO-C4X-320044)
- Avatrombopag Impurity 63 (CAS CATO-C4X-223463)
- 4-(5-Bromomethyl-isoxazol-3-yl)-benzoic Acid (CAS 1199773-70-0)
- 5-Chloro-N-(2-(3,5-dimethylphenoxy)ethyl)thiophene-2-sulfonamide (CAS 1105235-72-0)
- 7,7-Difluoro-1-methylbicyclo[4.1.0]heptan-3-one, 97% (CAS 1557247-48-9)
- 3-(1-Benzoylpiperidin-4-yl)propanoic acid (CAS 75999-93-8)
- Val-Cit (CAS 159858-33-0)
- 8-(4-Nitrophenyl)-5,12,14-trioxa-2-azatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1(9),3(7),10,15-tetraen-6-one (CAS 342421-43-6)
- Tau Peptide (244-274) (Repeat 1 Domain) trifluoroacetate salt (CAS 330456-24-1)
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