Diclofenac sodium Impurity 63 CAS 1254576-93-6
| CAS No. | 1254576-93-6 |
| Molecular Formula | C14H9Cl2NO3 |
| Molecular Weight | 310.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Diclofenac sodium Impurity 63 (CAS 1254576-93-6) is a certified pharmaceutical impurity reference standard with the molecular formula C14H9Cl2NO3 and a molecular weight of 310.13 g/mol.
Structurally, Diclofenac sodium Impurity 63 (C14H9Cl2NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 310.13 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C14H9Cl2NO3 |
| Molecular Weight | 310.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Diclofenac Standards
- Diclofenac sodium Impurity 48 (CAS 66156-75-0)
- Diclofenac Related Compound 1 (CAS 928343-25-3)
- Diclofenac Methyl Ester (Aceclofenac EP Impurity B) (CAS 15307-78-5)
- Diclofenac Impurity 42 (CAS 944251-06-3)
- Diclofenac Impurity 44 (CAS 69002-85-3)
- Diclofenac Impurity 23 (CAS CATO-C4X-105123)
- Diclofenac impurity f (CAS 124426-56-8)
- Diclofenac sodium Impurity 37 (CAS 15308-01-7)
Recommended Standards
- 3-[5-(4-bromophenyl)-4-methyl-1,3-oxazol-2-yl]propanoic acid (CAS 1016515-82-4)
- 1022890-00-1 2-((2-Bromo-3-oxocyclohex-1-enyl)amino)benzoic acid MFCD00129281 (CAS 1022890-00-1)
- N1-(4-Iodophenyl)benzene-1,4-diamine (CAS 944693-01-0)
- Ethyl 7-acetyl-3-bromo-1H-indole-2-carboxylate (CAS 1026775-55-2)
- Budesonide Impurity 53 (CAS CATO-C4X-138953)
- CAS 864272-34-3 (CAS 864272-34-3)
- Pranoprofen Impurity 40 (CAS CATO-C4X-181140)
- 2-(2-(Benzylthio)thiazol-4-yl)acetic acid (CAS 914205-99-5)
- Indometacin Impurity 32 (CAS CATO-C4X-147032)
- Methyl 3-cyano-1-naphthoate (CAS 496788-91-1)
- Ethyl 3-hydroxy-5-methylhexanoate (CAS 40309-43-1)
- (1-Methylisoquinolin-8-yl)methanol (CAS 136602-82-9)
- Tamsulosin Impurity 30 (CAS 589-10-6)
- Semaglutide impurity 28 (CAS CATO-C4X-222628)
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