Diclofenac sodium Impurity 48 CAS 66156-75-0
| CAS No. | 66156-75-0 |
| Molecular Formula | C14H9Cl2NO3 |
| Molecular Weight | 310.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 310.13 g/mol gives Diclofenac sodium Impurity 48 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Diclofenac sodium Impurity 48 (CAS 66156-75-0), a pharmacopoeial impurity reference standard (molecular formula C14H9Cl2NO3, MW 310.13 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Diclofenac sodium Impurity 48 (C14H9Cl2NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Diclofenac sodium Impurity 48 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H9Cl2NO3 |
| Molecular Weight | 310.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Diclofenac Standards
- Diclofenac Related Compound 1 (CAS 928343-25-3)
- Diclofenac sodium Impurity 63 (CAS 1254576-93-6)
- Diclofenac Methyl Ester (Aceclofenac EP Impurity B) (CAS 15307-78-5)
- Diclofenac Impurity 42 (CAS 944251-06-3)
- Diclofenac Impurity 44 (CAS 69002-85-3)
- Diclofenac Impurity 23 (CAS CATO-C4X-105123)
- Diclofenac impurity f (CAS 124426-56-8)
- Diclofenac sodium Impurity 37 (CAS 15308-01-7)
Recommended Standards
- N1-(4-Iodophenyl)benzene-1,4-diamine (CAS 944693-01-0)
- methyl 3-iodo-1H-indazole-7-carboxylate (CAS 944899-05-2)
- methyl 3-iodo-1H-indazole-5-carboxylate (CAS 885271-25-0)
- 3-[5-(4-bromophenyl)-4-methyl-1,3-oxazol-2-yl]propanoic acid (CAS 1016515-82-4)
- Oxymetazoline Impurity 3 HCl (CAS 205035-03-6)
- Metronidazole Impurity N30 (CAS 56910-52-2)
- Atracurium Impurity 71 (CAS CATO-C4X-185071)
- N-(4-(1H-Pyrrol-1-yl)phenyl)-2,2,2-trifluoroacetamide (CAS 1789466-57-4)
- (1S,2R)-2-((tert-Butoxycarbonyl)amino)cycloheptane-1-carboxylic acid (CAS 1335031-78-1)
- 4-Chloro-3-(difluoromethyl)-2-methoxy-5-nitropyridine (CAS 1807083-01-7)
- 1-(2-Bromopropyl)-3-chlorobenzene (CAS 216581-36-1)
- Rel-cyclohexanamine ((5-(dimethylamino)naphthalen-1-yl)sulfonyl)-L-threoninate (CAS 84540-66-9)
- 2-(3-Chloropropyl)-5-methoxy-1h-imidazo[4,5-b]pyridine hydrochloride (CAS 1432679-12-3)
- Semaglutide impurity 65 (CAS CATO-C4X-222665)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com