Diclofenac Impurity 44 CAS 69002-85-3
| CAS No. | 69002-85-3 |
| Molecular Formula | C14H11Cl2NO3 |
| Molecular Weight | 312.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Diclofenac Impurity 44 (CAS 69002-85-3, C14H11Cl2NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Diclofenac Impurity 44 (C14H11Cl2NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H11Cl2NO3 |
| Molecular Weight | 312.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Diclofenac Standards
- Diclofenac Impurity 42 (CAS 944251-06-3)
- Diclofenac Impurity 23 (CAS CATO-C4X-105123)
- Diclofenac Methyl Ester (Aceclofenac EP Impurity B) (CAS 15307-78-5)
- Diclofenac sodium Impurity 48 (CAS 66156-75-0)
- Diclofenac Related Compound 1 (CAS 928343-25-3)
- Diclofenac sodium Impurity 63 (CAS 1254576-93-6)
- Diclofenac impurity f (CAS 124426-56-8)
- Diclofenac sodium Impurity 37 (CAS 15308-01-7)
Recommended Standards
- Ornidazole Impurity 69 (CAS CATO-C4X-133169)
- 5-Hydroxy Diclofenac (CAS 69002-84-2)
- 4-(4-Bromophenyl)-2-(cyclopropylamino)-4-oxobutanoic acid (CAS 1024685-41-3)
- 4'-Hydroxy Diclofenac (CAS 64118-84-9)
- Betahistine impurity N3 (CAS 562101-24-0)
- Lacosamide EP Impurity D Oxalate (CAS 1379592-19-4)
- Semaglutide impurity 29 (CAS 1188328-22-4)
- 3-((3-Hydroxyphenyl)(propyl)amino)propane-1-sulfonic acid (CAS 102362-80-1)
- Lauroylcholine Chloride (CAS 25234-60-0)
- 2-Chloro-N-(1,1-dioxo-1λ6-thiolan-3-yl)-N-(thiophen-2-ylmethyl)acetamide (CAS 852940-43-3)
- N-((5-Fluorothiophen-2-yl)methyl)-1-isopropyl-1H-pyrazol-3-amine hydrochloride (CAS 1856063-75-6)
- 5-(2-Furyl)thieno[2,3-d]pyrimidin-4(3H)-one (CAS 256507-00-3)
- tert-Butyl (4-chloro-2-iodophenyl)carbamate (CAS 1017279-64-9)
- Compstatin control peptide (CAS 301544-78-5)
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